Meta-analysis of the efficacy of Maxing Shigan decoction combined with western medicine in the treatment of community-acquired pneumonia in children
Objective To systematically evaluate the efficacy and safety of Maxing Shigan decoction combined with conventional western medicine in the treatment of pneumonia in children.Methods Randomized controlled trials of combined use of Maxing Shigan decoction in the treatment of childhood pneumonia were searched by computer in the databases at home and abroad,which were published from the establishment of databases to August 1,2023.Two researchers conducted literature screening and data extraction separately,and the quality of the included studies was evaluated.Meta-analysis was performed using RevMan 5.3 software.Results A total of 9 studies were included,involving a total of 1 005 patients,including 504 patients in the experimental group and 501 patients in the control group.The results of Meta-analysis showed that the total effective rate of combined use of Maxing Shigan decoction in the treatment of children with pneumonia[RR=1.16,95％CI(1.11,1.22),P＜0.000 01],the time of cough disappearance[SMD=-1.60,95％CI(-1.81,-1.39),P＜0.000 01],fever relief time[SMD=-1.43,95％CI(-2.04,-0.82),P＜0.000 01],lung rale disappearance time[SMD=-1.35,95％CI(-1.55,-1.15),P＜0.000 01],and the levels of serum CRP after treatment in the experimental group were better than those of control group,and the incidence of adverse reactions and complications was better than that of control group[RR=0.41,95％CI(0.18,0.95),P=0.04].Conclusion Maxing Shigan decoction combined with conventional western medicine is effective,and is also safer than conventional western medicine in the treatment of children with pneumonia,but high-quality RCT studies are needed for further verification.
万方数据
维普
