Risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children:a systematic review and Meta-analysis
Objective To systematically evaluate the risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children.Methods Computer retrieval was conducted in PubMed,Embase,Web of Science,Cochrane Library,CBM,Chinese Medical Journal Full-text Database,Wanfang Database,VIP and CNKI to collect related studies on risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children.The retrieval period was from the establishment of the databases to February 2024.Meta-analysis was performed using Stata 18.0 and RevMan 5.4 software.Results A total of 17 studies were included,all being case-control studies,involving 4 336 children.The results of Meta-analysis showed that fever duration[OR=4.45,95％CI(3.32-5.96),P＜0.001],C-reactive protein(CRP)[OR=1.45,95％CI(1.28-1.65),P＜0.001],D-dimer[OR=2.21,95％CI(1.27-3.85),P=0.005],neutrophil ratio(N％)[OR=1.47,95％CI(1.17-1.85),P=0.001],pleural effusion[OR=3.63,95％CI(2.77-4.76),P＜0.001],atelectasis[OR=4.03,95％CI(2.46-6.63),P＜0.001]and allergy history[OR=3.04,95％CI(2.39-3.78),P＜0.001]were positively correlated with Mycoplasma pneumoniae pneumonia complicated with plastic bronchitis in children,while lymphocyte ratio(L％)[OR=0.71,95％CI(0.52-0.96,P=0.030)]was negatively correlated with it,and lactate dehydrogenase(LDH)[OR=1.02,95％CI(1.00-1.03),P=0.020]was not an influencing factor for it.Conclusion Current evidence shows that the longer the fever duration,the higher the proportion of CRP,D-dimer and neutrophils,and the lower the proportion of lymphocytes;combination with atelectasis,pleural effusion,and allergic history are risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children.
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