Objective To explore the value of global registry of acute coronary events(GRACE)score com-bined with white blood cell(WBC)count to mean platelet volume ratio(WMR)in predicting the occurrence of in-hospital major adverse cardiovascular events(MACE)after emergency percutaneous coronary intervention(PCI)in acute ST-segment elevation myocardial infarction(STEMI)patients.Methods The clinical data of 349 STEMI patients who received emergency PCI treatment in Xiangyang Central Hospital from January 2021 to March 2022 were retrospectively analyzed.According to the occurrence of in-hospital MACE,the patients were divided into MACE group(n=47)and non-MACE group(n=302).The clinical data of the patients in different groups were compared.Cox regression was used to analyze the risk factors for the occurrence of in-hospital MACE after PCI in the STEMI patients,and ROC curve analysis was used to evaluate the value of GRACE score combined with WMR in predicting the occurrence of in-hospital MACE after PCI in the STEMI patients.Results Compared with the non-MACE group,the MACE group were older,and had lower systolic blood pressure,diastolic blood pressure and left ventricular ejection fraction(LVEF),and higher heart rate,rates of Killip grade≥Ⅱ,GRACE score,WBC,WMR,neutrophil-to-lymphocyte ratio(NLR),fasting plasma glucose(FPG),creatinine(Cr),alanine aminotransferase(ALT),aspartate transaminase(AST),and crea-tine kinase MB isoenzyme(CK-MB),and the differences were statistically significant(P＜0.05).The results of mul-tivariate Cox regression analysis showed that higher levels of GRACE score and WMR were independent risk factors for promoting the occurrence of in-hospital MACE in the STEMI patients(P＜0.05).The results of ROC curve analysis showed that both GRACE score and WMR were effective in predicting the occurrence of in-hospital MACE after PCI in the STEMI patients(P＜0.05),and the combined prediction efficiency of the two indicators was better[AUC(95％CI)=0.824(0.750-0.897),P＜0.001],and the sensitivity and specificity were 74.50％and 80.50％,respectively.Conclusion The combination of GRACE score and WMR has good predictive value for in-hospital MACE in STEMI patients after PCI,which helps clinical workers to make more accurate risk stratification and treatment decisions.
Acute ST-segment elevation myocardial infarction(STEMI)Global registry of acute coronary events(GRACE)scoreWhite blood cell count to mean platelet volume ratio(WMR)Major adverse cardiovas-cular events(MACE)Risk predictionPercutaneous coronary interven
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