Objective To explore the expression of engulfment and cell mobility 3(ELMO3)in pancreatic carcinoma and its clinical significance.Methods One hundred and twenty-eight pancreatic carcinoma specimens were collected from the General Hospital of Xinjiang Military Region(63 cases)and Luoyang Central Hospital Affiliated to Zhengzhou University(65 cases)between January 2000 and December 2007,and other 11 cases of normal pancreatic tissue specimens adjacent to pancreatic carcinoma(about 3 cm)were collected as controls.Western blot method and immunohistochemical staining method were used to detect the expressions of ELMO3 in pancreatic carcinoma tissues and adjacent normal pancreatic tissues,and the correlation between ELMO3 expression and the clinicopathological indica-tors and the prognosis of the pancreatic carcinoma patients were analyzed.Results The positive rate of ELMO3 in the pancreatic carcinoma tissues was higher than that in the adjacent normal pancreatic tissues,and the difference was sta-tistically significant(83.59％vs 27.27％;x2=16.199,P＜0.001).The results of Western blot detection showed that the ELMO3 expression level in the pancreatic carcinoma tissues was significantly higher than that in the adjacent normal pancreatic tissues(t=1.205,P=0.001).The expression of ELMO3 was significantly associated with tumor diameter,differentiation degree,TNM stage and lymph node metastasis in the pancreatic carcinoma patients(P＜0.05).The median survival time of the ELMO3-positive group was shorter than that of the ELMO3-negative group(11 months vs 35 months),and the survival prognosis of the ELMO3-negative group was better than that of the ELMO3-positive group(log-rank test:X2=58.602,P＜0.001).The results of Cox regression analysis showed that ELMO3-positive expression,distant metastasis and TNM stage Ⅲ/Ⅳ were independent risk factors for poor survival prognosis of the pancreatic carcinoma patients(P＜0.05).Conclusion ELMO3-positive expression is associated with malignant clinicopathological charac-teristics of pancreatic carcinoma and poor prognosis.
Pancreatic carcinomaEngulfment and cell mobility 3(ELMO3)Clinicopathological characteristicsPrognosis
维普
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