Analysis on CCTA high-risk plaque characteristics and correlation of the degree of coronary stenosis with abnormal coronary flow reserve fraction in patients with obstructive coronary artery disease
Objective To analyze coronary computed tomography angiography(CCTA)high-risk plaque char-acteristics and correlation of the degree of coronary stenosis with abnormal coronary flow reserve fraction in patients with obstructive coronary artery disease(CAD).Methods The clinical data of 139 patients who underwent CCTA and were diagnosed with CAD in the First Affiliated Hospital of Hebei North University from January 2017 to June 2018 were ret-rospectively analyzed,and 205 coronary arteries were enrolled.All the enrolled coronary arteries were divided into abnormal computed tomography(CT)-derived fractional flow reserve(FFRCT)group(FFRCT ≤0.80,117 vessels)and normal FFRCT group(FFRCT＞0.80,88 vessels)according to different values of FFRCT.The characteristics of high-risk plaques and the degree of coronary stenosis were compared between the two groups.The effects of the degree of coronary stenosis and the characteristics of high-risk plaques on FFRCT abnormalities were analyzed by using logistic regression.Results The incidence rates of positive remodeling(PR)and low attenuation plaque(LAP)in the abnormal FFRCT group were significantly higher than those in the normal FFRCT group(P＜0.05).There was a statistically significant difference in the degree of coronary artery stenosis between the two groups(P＜0.05).Severe coronary stenosis,LAP and PR were independent risk factors of promoting abnormal FFRCT(P＜0.05).Conclusion CCTA severe coronary artery stenosis,LAP and PR are closely related to abnormal FFRCT,which is helpful to guide clinical practice to better identify patients with hemodynamic abnormalities.
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