摘要
特应性皮炎是一种常见的慢性、炎症性、系统性皮肤病,其主要的临床特征为皮肤干燥、瘙痒和慢性湿疹样皮损.特应性皮炎的发病机制尚不完全清楚,一般认为与遗传、环境和免疫紊乱导致的Th2型炎性细胞因子的异常表达有关,因而通过阻断Th2型炎症信号通路达到抑制Th2炎性细胞因子转录是目前临床治疗和新药开发的主流.我国传统中医药治疗特应性皮炎具有数百年的历史以及良好的疗效.最近几十年间中药中抗炎活性物质的功能和机制也不断被发现和揭示.研究显示,多种中药活性物质通过抑制Th2炎性细胞因子的转录来实现其抗炎效应.在此,本文综述了近来报道的对特应性皮炎具有治疗作用且转录调控Th2炎性细胞因子的中药活性物质的相关进展.
Abstract
Atopic dermatitis(AD)is a chronic,inflammatory and systemic skin disease,which involves dry,itchy and eczema-like skin lesions.Currently,the mechanisms of AD pathogenesis remain undear.Excessive expression of Th2 cytokines,which are triggered by genetic susceptibility,environmental antigens and immune disorders,is considered as the major cause of AD.Therefore,targeting of Th2 signaling to repress expression of Th2 cytokines is the leading filed in AD therapy and drug development.In China,the traditional Chinese medicine(TCM)has been used for treating AD for over centuries and shown therapeutic effect.In the past decades,the ingredients with anti-inflammation activities in TCM have been exploring and revealing.It also has been suggested that the active ingredients exert their anti-inflammation effects through repression of Th2 cytokines transcription.Here,this paper reviews the TCM ingredients which improve AD skin lesions and potentially regulate the Th2 cytokines transcription.
基金项目
国家自然科学基金面上项目(82174202)
四川省自然科学基金面上项目(2022NSFSC0726)
上海市启明星计划扬帆专项项目(22YF1449700)
维普
万方数据