皮肤科学通报2024,Vol.41Issue(3) :299-304.

三亚油酸甘油酯对皮肤屏障的保护作用研究

Protective Effect of Trilinolein on Skin Barrier

程淋燕 王怡 卫颖漪 奚若凡 刘欣 郭冬婕 朱建勇 李福伦
皮肤科学通报2024,Vol.41Issue(3) :299-304.

三亚油酸甘油酯对皮肤屏障的保护作用研究

Protective Effect of Trilinolein on Skin Barrier

程淋燕 1王怡 1卫颖漪 1奚若凡 1刘欣 1郭冬婕 1朱建勇 2李福伦1
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作者信息

  • 1. 上海中医药大学附属岳阳中西医结合医院皮肤科,上海 200437
  • 2. 上海中医药大学附属岳阳中西医结合医院药学研究室,上海 200437
  • 折叠

摘要

目的 观察三亚油酸甘油酯乳膏的保湿及保护皮肤屏障的效果.方法 招募16例健康受试者,检测三亚油酸甘油酯乳膏给药前、后该部位皮肤的水份、油脂含量以及皮肤张力.采用随机盲法实验,将不同浓度三亚油酸甘油酯乳膏及其他润肤产品共5种进行分装,并编号1~5.招募59例健康受试者对5种产品的保湿、滋润等使用效果进行检测.结果 三亚油酸甘油酯乳膏给药后,受试者皮肤水份含量在涂抹后即刻提高了约38.83%,2 h后皮肤仍有较高水分含量(P<0.05),油脂及张力在涂抹前后差异无明显统计学意义.随机盲法实验的5种产品的保湿、滋润效果差异均无统计学意义.结论 三亚油酸甘油酯乳膏外用具有良好的保湿效果,并且不会增加皮肤的油脂含量.而三亚油酸甘油酯在保湿、滋润等方面与目前上市常见润肤产品相当.

Abstract

Objective To observe the moisturizing and protective effect on skin barrier of trilinolein.Methods Sixteen healthy volunteers were recruited and their skin moisture content,oil content and skin tone were measured before and after application of trilinolein cream.Five different samples containing different concentrations of trilinolein and other emollients were divided into identical vacuum dispensing bottles and numbered 1-5.59 healthy volunteers were recruited to blindly test the moisturising and nourishing effects of the five products.Results Following the administration of trilinolein cream,the volunteers'skin moisture content increased by approximately 38.83%immediately after application,and the skin still had a high moisture content 2 hours later(P<0.05),and there was no significant difference in oil and tension before and after application.There was no statistically significant difference in the moisturizing effect of the five products in the randomised,blinded study.Conclusion Topical application of trilinolein cream has been demonstrated to have a beneficial moisturising effect on the skin.Furthermore,trilinolein cream does not appear to increase the oil content of the skin.In terms of moisturisation and nourishment,trilinolein cream is comparable to other emollient products currently available on the market.

关键词

三亚油酸甘油酯乳膏/特应性皮炎/皮肤屏障/保湿

Key words

Trilinolein/Atopic dermatitis/Skin barrier/Moisturizing

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基金项目

上海市科学技术委员会(23Y31920300)

上海市科学技术委员会(23015821100)

国家中医药管理局皮肤病中医特色疗法循证能力建设()

上海市卫生健康委员会(202340074)

出版年

2024
皮肤科学通报
西安交通大学

皮肤科学通报

CSTPCD
影响因子:0.273
ISSN:1001-8077
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