Efficacy and Safety of External Treatment of Traditional Chinese Medicine Combined with 5-Aminolevulinic Acid Photodynamic Therapy for Moderate to Severe Acne
Objective To investigate the efficacy and safety of external treatment of traditional Chinese medicine(TCM)combined with 5-aminolevulinic acid photodynamic therapy for moderate to severe acne.Methods According to the different treatment methods from inclusion and exclusion criteria,52 patients were divided into treatment group and control group.The treatment group was given TCM external treatment combined with photodynamic therapy,and the control group was only given photodynamic therapy.Each group was treated for 3 times with a total course of 6 weeks.The effective rate,adverse reactions,improvement of quality of life were compared between the two groups.Results After 12 weeks treatment,the Global Acne Grading System scores of both groups showed a significant decrease compared with the condition before treatment.Additionally,the scores of the treatment group were lower than those of the control group(P＜0.05).The total effective rate in the treatment group(92.30％)was significantly higher than that in the control group(84.70％,P＜0.05).The main adverse reactions observed in the treatment group were pain.The other primary adverse reactions observed in both groups were transient edema and erythema,which could be effectively managed with symptomatic treatment,indicating a good safety profile.Conclusion The combination of TCM external treatment and photodynamic therapy has demonstrated efficacy in the management of moderate to severe acne,which is better than photodynamic therapy alone.This approach is associated with fewer adverse reactions and a favorable safety profile,thus warranting further clinical application.
External treatment of traditional Chinese medicineFire needle5-aminolevulinic acidPhotodynamic therapyModerate to severe acne
万方数据
维普
