A型肉毒毒素在带状疱疹后遗神经痛中的疗效及作用机制
Therapeutic Effect and Mechanism of Botulinum Toxin A in Postherpetic Neuralgia
张银连 1张景瑜 2柴宝 2肖礼祖 3郑跃 4陈宏翔5
作者信息
- 1. 深圳市前海蛇口自贸区医院,广东深圳 518055
- 2. 深圳市南山区人民医院,深圳大学医学院附属第六医院皮肤科,广东深圳 518052
- 3. 深圳市南山区人民医院,深圳大学医学院附属第六医院疼痛科,广东深圳 518052
- 4. 南方医科大学南方医院皮肤科,广东广州 510515
- 5. 华中科技大学同济医学院附属协和医院皮肤科,湖北武汉 430022
- 折叠
摘要
带状疱疹后遗神经痛(postherpetic neuralgia,PHN)是带状疱疹最常见的并发症,以疱疹部位皮肤烧灼或电击样疼痛为表现,常引起睡眠障碍、焦虑、抑郁等不良结果,严重影响患者的生活质量、身体机能和心理健康,给个人和社会带来相应的医疗和经济负担.随着社会发展,人口老龄化,PHN发病率将逐年增高.肉毒毒素是一种神经毒性蛋白,研究表明,A型肉毒毒素(botulinum toxin-A,BTX-A)能够显著缓解PHN改善患者生活质量,但其作用机制尚未阐明.本文就BTX-A治疗PHN的有效性、安全性及作用机制的研究现状作一阐述,希望为临床医生治疗PHN提供帮助和指导.
Abstract
Postherpetic neuralgia(PHN)is the most common complication of herpes zoster,characterized by a burning or electric-shock like pain at the site of the blister.It often leads to adverse effects such as sleep disorders,anxiety,and depression.Patients with PHN have reduced quality of life,physical functioning,and psychological well-being,resulting in a health care and economic burdens at both the individual and societal levels.The frequencies of postherpetic neuralgia increase with age.Botulinum toxin A(BTX-A)is a neurotoxic protein that has been shown to significantly alleviate PHN and improve patient quality of life.However,the mechanism has not been elucidated.This review will discuss current research progress on the effectiveness,safety,and mechanism of BTX-A in the treatment of PHN,hoping to provide assistance and guidance for clinical doctors.
关键词
A型肉毒毒素/带状疱疹后遗神经痛/镇痛/作用机制Key words
Botulinum toxin A/Postherpetic neuralgia/Analgesia/Mechanism引用本文复制引用
基金项目
国家自然科学基金面上项目(82173423)
深圳市基础研究专项(自然科学基金)基础研究面上项目(JCYJ20210324112213036)
深圳市南山区卫生健康系统科技重大项目(NSZD2023007)
深圳市南山区卫生健康系统科技重大项目(NSZD2023051)
深圳市南山区卫生科技项目(NS2022027)
出版年
2024
NETL
NSTL
万方数据