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面部原发性皮肤黏液癌1例

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患者男,69岁,右侧面部肿物8年余.8年前患者无明显诱因出现右侧面部肿物,无红肿、疼痛,未予重视,后肿物逐渐增大.患者既往类风湿性关节炎13年.体检:一般情况尚可,全身浅表淋巴结未触及增大;四肢关节畸形,尤以双下肢为著,呈屈膝状,活动受限无水肿.皮肤科情况:右侧面部颧部外上方可见一约3.5 cm×4.0 cm大小红色肿物,表面血管扩张,质中等,活动度尚可,无压痛及波动感.皮损组织病理示:瘤组织位于真皮层内,由大小不一的肿瘤细胞团构成,漂浮于黏液湖中.免疫组织化学示:细胞角蛋白7(CK7)弥漫+,囊肿病液体蛋白-15(GCDFP-15)+,Ki67阳性指数5%~10%,突触素(Syn)、嗜铬素A(CgA)、S100和CK20均阴性.诊断:面部原发性皮肤黏液癌.行肿物切除术,随访至今无复发.
Primary Cutaneous Mucinous Carcinoma on Facial:A Case Report
A 69-year-old man presented with a right facial mass for more than 8 years.Eight years ago,the patient developed a mass on the right side of the face without obvious cause.There was no redness,swelling,or pain.The patient had a history of rheumatoid arthritis for 13 years.Physical examination showed that the general condition was acceptable,and the superficial lymph nodes of the whole body were not palpable.Joint deformities of the extremities,especially the lower limbs,were knee-flexed,with limited movement and no edema.Skin examination revealed a 3.5 cm × 4.0 cm red mass on the right side of the zygomatic region.The mass had dilated blood vessels on the surface,medium texture,and good mobility,without tenderness or fluctuation.Histopathological examination showed that the tumor tissue was located in the dermis and consisted of tumor cell clusters of different sizes floating in a mucus lake.Immunohistochemical study showed diffuse positivity for cytokeratin 7(CK7),cystic disease fluid protein-15(GCDFP-15),and Ki67 positive index of 5%-10%.Syn,CgA,S100 and CK20 were all negative.The diagnosis was primary mucinous carcinoma of the skin.The tumor was resected and no recurrence was found during follow-up.

Mucinous carcinomaPrimaryFacial skin

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甘肃省酒泉市第二人民医院放疗科,甘肃酒泉 735000

皮肤黏液癌 原发性 面部

2024

皮肤科学通报
西安交通大学

皮肤科学通报

CSTPCD
影响因子:0.273
ISSN:1001-8077
年,卷(期):2024.41(4)
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