首页|心脏磁共振分形分析评估肥厚型心肌病心肌小梁特征的初步研究

心脏磁共振分形分析评估肥厚型心肌病心肌小梁特征的初步研究

Trabecular Characteristics of Hypertrophic Cardiomyopathy Based on Cardiac Magnetic Resonance Fractal Analysis:A Preliminary Study

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目的 探讨心脏磁共振分形分析技术评价肥厚型心肌病(HCM)左心室心肌小梁复杂性的可行性,研究小梁复杂性与左心室心功能的关系.资料与方法 回顾性分析 2020 年 8 月—2022 年 12 月南昌大学第二附属医院收治的 80 例HCM患者和80 名志愿者(对照组).测量HCM组与对照组心功能参数及左心室心肌小梁分形维数(FD),比较两组左心室整体FD、最大基底FD、最大心尖FD的差异,采用受试者工作特征曲线评价FDs诊断HCM的效能,分析FDs与左心结构及功能参数的相关性.结果 HCM组左心室整体FD高于对照组,差异有统计学意义(1.303±0.047比1.229±0.026;t=-12.387,P<0.001).左心室整体 FD 鉴别 HCM 与对照组的诊断效能最佳,以 1.251 为诊断 HCM 的最佳截断值时,曲线下面积为 0.933(95%CI 0.896～0.969).左心室整体FD与最大室壁厚度及心肌质量指数呈正相关(r=0.686、0.687,P<0.001),平均心尖FD与左心室射血分数呈正相关(r=0.520,P<0.001).结论 心脏磁共振分形分析技术得到的FD对诊断HCM有明确价值,并与左心结构及功能存在相关性.
Purpose To evaluate the feasibility of cardiac magnetic resonance fractal analysis in evaluating left ventricular trabecular complexity in hypertrophic cardiomyopathy(HCM),and to study the degree of left ventricular trabecular complexity in HCM and the relationship between excessive trabecular complexity and cardiac function.Materials and Methods From August 2020 to December 2022,a total of 80 patients with HCM from the Second Affiliated Hospital of Nanchang University were retrospectively analyzed.Additionally,80 healthy volunteers were recruited as the control group.Left ventricular functional parameters and fractal dimension(FD)of left ventricular trabecular myocardium were measured.The differences of mean global FD,max basal FD and max apical FD were compared between the HCM group and the control group,the correlation between FDs and cardiac function parameters was evaluated.The diagnostic efficiency of mean global FD,max apical FD and max basal FD was analyzed via receiver operating characteristic curve.Results The mean global FD of HCM group was significantly higher than that of normal group,and the difference was statistically significant(1.303±0.047 vs.1.229±0.026;t=-12.387,P<0.001).Mean global FD showed the best performance in differentiating HCM from normal control group.The optimal cut-off value for the diagnosis of HCM was 1.251,with the area under curve of 0.933(95%CI 0.896-0.969).Mean global FD was positively correlated with maximum wall thickness and left ventricular mass index(r=0.686,0.687,P<0.001),and max apical FD was positively correlated with left ventricular ejection fraction(r=0.520,P<0.001).Conclusion The FD obtained by cardiac magnetic resonance fractal analysis technique is reproducible and has definite value in the diagnosis of HCM,with association with the structure and function of left heart.

Cardiomyopathy,hypertrophicMyocardiumMagnetic resonance imagingImage processing,computer-assistedFractal analysisFractal dimension

张鑫、周晶晶、温金扬、郑甜、方淇民、肖轩、龚良庚

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南昌大学第二附属医院影像中心,江西 南昌 330006

心肌病,肥大性 心肌 磁共振成像 图像处理,计算机辅助 分形分析 分形维数

国家自然科学基金重点项目国家自然科学基金重点项目江西省自然科学基金重点项目

822603428186031620212ACB206021

2024

10.3969/j.issn.1005-5185.2024.01.010

中国医学影像学杂志
中国医学影像技术研究会

中国医学影像学杂志

CSTPCD北大核心
影响因子：1.37
ISSN：1005-5185
年,卷(期)：2024.32(1)
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