11C-CFT联合18F-FDG PET/CT脑显像在帕金森综合征鉴别诊断中的应用
Application of 11C-CFT Combined with 18F-FDG PET/CT Brain Imaging in Differential Diagnosis of Parkinson's Syndrome
包惠桢 1宋普姣2
作者信息
- 1. 贵州医科大学医学影像学院,贵州 贵阳 550000;郴州市第一人民医院核医学科,湖南 郴州 423000
- 2. 贵州医科大学附属医院核医学科,贵州 贵阳 550000
- 折叠
摘要
目的 评价帕金森综合征患者 11C-CFT与 18F-FDG PET/CT联合脑显像情况,检验双示踪剂联合显像在帕金森综合征鉴别诊断方面的临床应用价值.资料与方法 回顾性分析 2016 年 1 月—2021 年 2 月于贵州医科大学附属医院行 11C-CFT与 18F-FDG PET/CT双示踪剂联合脑显像的帕金森综合征患者 73 例,并分为帕金森病(PD)组 40 例、多系统萎缩(MSA)组 20 例和进行性核上性麻痹(PSP)组13例,选取 2020年9-10 月招募的10例健康受检者为正常对照组.分析各组脑显像图像特点,并对尾状核、壳核结合率指数和相应脑区的放射性摄取簇值等进行比较.结果 与正常对照组比较,病例组患者均存在多巴胺能系统受损情况,PD组具有显著不对称性,MSA组受损更均匀,PSP组患者多巴胺能系统受损最严重.葡萄糖代谢方面,MSA组小脑半球的葡萄糖代谢较其他组显著减低(P均<0.05).MSA组与正常对照组相比仅患侧丘脑的葡萄糖代谢增高,差异有统计学意义(P<0.05).PSP组及PD组与MSA组的中脑葡萄糖代谢差异有统计学意义(P<0.05).在额叶及前扣带回皮层方面,PSP组与正常对照组及PD组单侧或双侧大脑皮层葡萄糖代谢差异有统计学意义(P均<0.05).结论 双示踪剂可以弥补单示踪剂在鉴别诊断方面的不足,可对帕金森综合征进行准确的早期诊断.
Abstract
Purpose To evaluate the combined brain imaging of 11C-CFT and 18F-FDG PET/CT in Parkinson's syndrome,and to test the clinical value of dual tracer combined imaging in differential diagnosis of Parkinson's syndrome.Materials and Methods A retrospective analysis was made on 73 patients with Parkinson's syndrome who underwent 11C-CFT and 18F-FDG PET/CT dual tracer combined brain imaging in the Affiliated Hospital of Guizhou Medical University from January 2016 to February 2021.The patients were divided into Parkinson's disease(PD)group(n=40),multiple system atrophy(MSA)group(n=20),and progressive supranuclear palsy(PSP)group(n=13).Ten normal controls recruited from September to October 2020 were selected as the normal control group.The images were analyzed and summarized,and the caudate nucleus index,putamen index as well as the radioactive uptake cluster values of the corresponding brain regions were compared.Results Compared with the normal control group,all three patient groups showed damage to the dopamine system.PD group showed significant asymmetry,MSA group had more uniform damage,and PSP group had the most severe damage to the dopamine system.In terms of glucose metabolism,the glucose metabolism in the cerebellar hemisphere of MSA group was significantly reduced compared with other groups(P<0.05).Compared with the normal control group,MSA group only had an increase in glucose metabolism in the diseased thalamus,and the difference was statistically significant(P<0.05).There was a statistically significant difference in midbrain glucose metabolism between PSP group and PD group compared with MSA group(P<0.05).In terms of frontal lobe and anterior cingulate cortex,there were significant differences in glucose metabolism between PSP group,normal control group,and PD group on one or both sides of the cerebral cortex(P<0.05).Conclusion Double tracer can make up for the deficiency of single tracer in differential diagnosis,so as to early make accurate diagnosis of Parkinson's syndrome.
关键词
帕金森病/帕金森综合征/多巴胺转运体显像/正电子发射断层摄影术/氟脱氧核糖F18Key words
Parkinson's disease/Parkinson's syndrome/11C-2-b-carbomethoxy-3b-(4-fluorophenyl)tropane/Positron-emission tomography/Fluorodeoxyribose F18引用本文复制引用
出版年
2024
NETL
NSTL
万方数据