缩短PET/CT采集时间对帕金森病诊断的影响
Effect of Shortening PET/CT Acquisition Time on the Diagnosis of Parkinson's Disease
李靖雯 1赵睿玥 1符乙敏 1许立夫 1梁思浩 1王欣璐1
作者信息
- 1. 广州医科大学附属第一医院核医学科,广东 广州 510000
- 折叠
摘要
目的 探究缩短氘代-氟[18F]丙那嗪(18F-D6-AV133)PET/CT采集时间对图像质量及帕金森病诊断效能的影响,减少长时间显像造成的运动伪影.资料与方法 回顾性选取2021年10月—2022年6月广州医科大学附属第一医院帕金森病患者27例与健康对照者24例,受试者注射示踪剂 18F-D6-AV133(371.04±16.30)MBq,60 min后进行图像采集,时长10 min.应用CT衰减校正重建为采集时间3、5、7、10 min的4组图像,对所得PET图像进行半定量分析,计算纹状体相对枕叶的标准化摄取值比值(SUVR),2位医师分别对不同组图像进行定性分析.比较不同采集时间SUVR、视觉评分的差异,使用受试者工作特征曲线分析获得SUVR最佳临界值.结果 2位医师图像质量视觉分析一致性较强(ICC=0.853,P<0.001),采集时间为5 min的图像能达到临床工作中普遍的质量水平,占78.4%(40/51).图像质量半定量结果显示,采集时间5 min和10 min所得SUVR与诊断效能差异无统计学意义(Z=1.821,P=0.069),且两组最佳临界值一致,均为3,即适当缩短采集时间对帕金森病诊断结果无影响.结论 随着技术设备的发展进步,PET图像质量逐步提高,扫描时间逐渐缩短,可以将 18F-D6-AV133采集时间从常规的10 min缩短为5 min.
Abstract
Purpose To investigate the effect of shortening the acquisition time of 18F-D6-AV133 PET/CT on image quality and diagnostic efficacy in Parkinson's disease.Materials and Methods A total of 51 participants(27 of Parkinson's disease,24 of healthy-controls)from the First Affiliated Hospital of Guangzhou Medical University from October 2021 to June 2022 were retrospectively selected.Images were obtained after the injection of the tracer 18F-D6-AV133(371.04±16.30)MBq for 60 min,with collection times of 10 min.Four sets of images were reconstructed using CT attenuation correction with acquisition times of 3,5,7 and 10 min.Semi-quantitative analysis was performed on the PET images,calculating the striatum-to-occipital lobe standardized uptake value ratio(SUVR).Two physicians independently conducted qualitative evaluations for each image group.The differences of SUVR and visual score results among four sets of images were performed.The optimal critical value of SUVR was obtained by analyzing the receiver operating characteristic curve of the subjects.Results The visual analysis of image quality had a strong consistency between the two doctors(ICC=0.853,P<0.001).The images with acquisition time of 5 min could reach the common quality level in clinical work,accounting for 78.4%(40/51).The semi-quantitative results of image quality showed that there was no significant difference between SUVR and diagnostic efficiency obtained by acquisition time 5 min and 10 min(Z=1.821,P=0.069),and the best critical value of the two groups was equal to 3.Therefore,properly shortening the acquisition time had no effect on the diagnosis of Parkinson's disease.Conclusion With the development and advancement of technical equipment,PET image quality is gradually improving and the scanning time is also gradually shortening.The acquisition time for 18F-D6-AV133 can be shortened from the conventional 10 min to 5 min.
关键词
帕金森病/正电子发射断层摄影术/采集时间/Ⅱ型囊泡单胺转运体显像/图像质量Key words
Parkinson's disease/Positron-emission tomography/Collection time/VMAT2 targeting imaging agent/Image quality引用本文复制引用
出版年
2024
NETL
NSTL
万方数据