帕金森病脑PET葡萄糖代谢模式研究进展
Progress on Cerebral Glucose Metabolism Patterns of PET Imaging in Parkinson's Disease
杨畅 1宋天彬 1张春 1卢洁1
作者信息
- 1. 首都医科大学宣武医院放射与核医学科,北京 100053;磁共振成像脑信息学北京市重点实验室,北京 100053
- 折叠
摘要
帕金森病是常见的神经退行性疾病,严重影响患者的生存质量,其早期精准诊断是目前医学一大难题.PET 可无创、在体监测帕金森病患者早期脑病理生理改变,具有良好的临床应用价值.18F-FDG PET 脑葡萄糖代谢显像是获取最便利、应用最广泛的检测方法.目前已发现多种帕金森病脑内特异性脑代谢模式,对其早期诊断、鉴别诊断、病情监测及疗效判断均有良好效果.本文重点对帕金森病PET葡萄糖代谢模式进行综述,使其更好地应用于帕金森病的诊断.
Abstract
Parkinson's disease(PD)is a common neurodegenerative disease,which seriously affects the quality of life of patients.The early and accurate diagnosis of PD is still a major medical problem.Positron computed tomography(PET)can be used to monitor noninvasively the pathophysiological changes in the early stage of PD in vivo,which has good clinical application value.18F-FDG PET cerebral glucose metabolism imaging is the most convenient and widely used detection method.At present,a variety of specific cerebral metabolic patterns of PD have been found,which have good guidance for the early diagnosis,differential diagnosis,disease monitoring and curative efficacy judgment of PD.Therefore,this paper focuses on the review of the 18F-FDG PET cerebral glucose metabolism model related to PD,aiming to enable a better application of this technique to the diagnosis of PD.
关键词
帕金森病/正电子发射断层摄影术/氟脱氧葡萄糖F18/综述Key words
Parkinson's disease/Positron-emission tomography/Fluorodeoxyglucose F18/Review引用本文复制引用
出版年
2024
NETL
NSTL
万方数据