Purpose To investigate the clinical and CT imaging characteristics of elderly patients with coronavirus disease 19(COVID-19)combined with underlying respiratory disease.Materials and Methods The clinical,laboratory and chest CT imaging data of elderly COVID-19 patients admitted to the Department of Infectious Diseases of Beijing Shijitan Hospital of Capital Medical University in December 2022 were retrospectively included,72 elderly patients with COVID-19 were enrolled.The patients were divided into two groups according to whether they had underlying respiratory diseases(chronic bronchitis,emphysema),including 32 patients combined with underlying respiratory disease and 40 patients without underlying respiratory disease.The clinical and CT features of the two groups were analyzed.Results Compared with the group without underlying respiratory disease,higher percentage of elderly COVID-19 patients in the combined underlying respiratory disease group had dyspnea at the initial visit(34.4%vs.12.5%;χ2=4.922,P=0.027),C-reactive protein[40.6(19.9,67.8)mg/L vs.18.6(5.7,51.7)mg/L;Z=-2.119,P=0.034]and neutrophil percentage[73.4(64.3,80.6)%vs.67.5(61.7,73.8)%;Z=-1.961,P=0.049].In terms of CT imaging parameters,patients with underlying disease had more enlarged mediastinal lymph nodes[2.0(1.0,3.0)vs.1.0(0,2.0);χ2=-2.042,P=0.041].There was a higher proportion of honeycomb sign(21.9%vs.0,P=0.002),nodular(78.1%vs.51.3%;χ2=5.457,P=0.019),large patchy(81.3%vs.50.0%;χ2=7.525,P=0.006)and banded patterns(59.4%vs.30.0%;χ2=6.257;P=0.012).At the same time,the proportion of small airway wall thickening(100.0%vs.82.5%,P=0.015),branch dilatation(93.8%vs.57.5%;χ2=12.026,P=0.001),fibrous cable(90.6%vs.62.5%;χ2=7.500,P=0.006)and crazy-paving pattern(78.1%vs.45.0%;χ2=8.109,P=0.004)were higher.Conclusion In elderly COVID-19 patients with underlying respiratory disease,there are certain characteristics of clinical and CT imaging signs,which can provide guidance for early clinical diagnosis and treatment.
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