Purpose To explore the clinical and ultrasonographic manifestations of tumoral calcinosis(TC).Materials and Methods A total of 44 patients who had both preoperative ultrasonographic evaluation and pathological diagnosis of TC were enrolled in Sichuan Provincial People's Hospital from January 2016 to May 2022.Clinical data(age,gender,serum phosphate,serum alkaline phosphatase,serum calcium,tenderness)and ultrasonographic manifestations(lesion location,size,internal echogenicity,relationship with surrounding structures,blood flow signals)of each lesion were all described.Results There were 47 lesions in 44 patients with tumoral calcinosis,17 lesions were located on the buttocks,9 lesions were located in the limbs,and 33 lesions were painless masses.Serum calcium and alkaline phosphatase were normal in 44 patients,while serum phosphorus was elevated in 5 patients.Calcinosis neoplasm was mainly located in the skin layer,fat layer or muscle layer,and did not involve bone.The ultrasonographic manifestations of tumoral calcinosis were divided into three types:①nodular calcification accumulation type:41 lesions(87.23%)showed sandlike or granular calcification with nodular accumulation,and all nodules were accompanied by sound shadows.8 lesions had clear boundaries with narrow low gyrus vocal cords around them,and no obvious blood flow signal was observed;10 lesions had wide low gyrus vocal cords around them,and the boundaries were recognizable,and blood flow signal was abundant.②Cystic mass with calcification foci deposition type:4 lesions(8.51%)showed cystic mass with internal separation,cyst wall and separated multiple fine sand or granular calcification foci deposition with sound shadow,cystic mass boundary was not clear,and sparse blood flow signal was seen in the cyst wall.③Isolated coarse calcification foci:two foci(4.26%)showed isolated coarse calcification foci with wide loud shadow behind,clear boundary and no obvious blood flow signal.Conclusion Characteristic clinical and ultrasonogrphic manifestations are found in patients with TC.TC generally presents as a painless mass located in dermal,fatty and muscular layer in young people and mainly demonstrated three types without osseous involvement on ultrasonography.