孤立性轻中度侧脑室增宽与胎儿脑成熟的相关性
Correlation Between Isolated Mild to Moderate Ventriculomegaly and Fetal Brain Maturation
洪子涵 1杨梦莹 2杨迎宾 1徐梦莹 1李朋 1陈兵1
作者信息
- 1. 宁夏医科大学总医院放射科,宁夏 银川 750004
- 2. 宁夏医科大学总医院妇产中心功能检查部,宁夏 银川 750004
- 折叠
摘要
目的 利用胎儿脑成熟半定量评分(fTMS)研究孤立性轻中度侧脑室增宽(VM)的胎儿在妊娠中晚期是否存在脑发育异常.资料与方法 回顾性分析 2018 年 1 月—2022 年 10 月宁夏医科大学总医院接受胎儿MRI的 45 例正常胎儿和 78 例异常胎儿,使用fTMS对所有图像进行评分.通过线性回归评估正常和异常胎儿fTMS与孕龄的关系,并分析孤立性轻度和中度VM胎儿与正常胎儿的差异.结果 正常胎儿的fTMS与孕龄呈显著正相关(r=0.939,P<0.05),fTMS(Y)与孕龄(X)线性回归方程为:Y=-28.1+1.25X;孤立性轻度和中度VM组的fTMS与孕龄呈显著正相关(r=0.945、0.906,P均<0.05),fTMS(Y)与孕龄(X)线性回归方程为:Y=-28.46+1.24X、Y=-25.57+1.13X;正常胎儿、轻度VM、中度VM的fTMS分别为(10.55±4.25)分、(10.13±4.08)分、(9.22±3.77)分,49例孤立性轻度VM胎儿与正常胎儿的fTMS差异无统计学意义(t=1.651,P>0.05),29 例孤立性中度VM胎儿与正常胎儿的fTMS差异有统计学意义(t=2.306,P<0.05).结论 fTMS适用于常规临床使用,并对孤立性中度VM胎儿和正常胎儿脑成熟的差异敏感.
Abstract
Purpose To investigate the abnormal brain development in fetuses with isolated mild to moderate ventriculomegaly(VM)during the second and third trimesters of pregnancy by using semi-quantitative fetal total maturation score(fTMS).Materials and Methods A retrospective analysis was performed on 45 normal fetuses and 78 abnormal fetuses who underwent fetal MRI in the General Hospital of Ningxia Medical University from January 2018 to October 2022.fTMS was used to score all images.Linear regression was used to assess the relationship between fTMS and gestational age between normal and abnormal fetuses and to analyze the differences between fetuses with isolated mild and moderate VM and controls.Results In the control group,fetal fTMS was significantly positively correlated with gestational age(r=0.939,P<0.05).The linear regression equation between fTMS(Y)and gestational age(X)was as follows:Y=-28.1+1.25X.In the mild and moderate isolated VM groups,fTMS was positively correlated with gestational age(r=0.945,0.906,P<0.05).The linear regression equations of fTMS(Y)and gestational age(X)were:Y=-28.46+1.24X,Y=-25.57+1.13X.The average fTMS of healthy fetus,mild VM and moderate VM were(10.55±4.25)points,(10.13+4.08)points and(9.22±3.77)points,respectively.There was no significant difference in fTMS between the 49 fetuses with mild isolated VM and the control group(t=1.651,P>0.05).There was significant difference in fTMS between the 29 fetuses with moderate isolated VM and the control group(t=2.306,P<0.05).Conclusion fTMS is suitable for routine clinical use and sensitive to differences in brain maturation between fetuses with isolated moderate VM and healthy controls.
关键词
磁共振成像/胎儿/脑成熟半定量评分/孕龄Key words
Magnetic resonance imaging/Fetus/Semi-quantitative score of brain maturation/Gestational age引用本文复制引用
基金项目
宁夏回族自治区科技惠民计划专项(2022CMG03051)
宁医大总院[2023]394号2022年新入职硕士人才培养项目()
出版年
2024
NETL
NSTL
万方数据