胃肠道间质瘤基因型及靶向治疗疗效的影像学研究进展
Advances in Imaging of Genotype and Targeted Therapy Efficacy of Gastrointestinal Stromal Tumors
孙嘉晨 1任铁柱 1徐媛 1周俊林1
作者信息
- 1. 兰州大学第二医院放射科,兰州大学第二临床医学院,甘肃省医学影像重点实验室,医学影像人工智能甘肃省国际科技合作基地,甘肃 兰州 730030
- 折叠
摘要
胃肠道间质瘤(GISTs)是胃肠道最常见的间叶源性肿瘤,也是一种基因异质性肿瘤.c-KIT基因或PDGFRA基因突变是导致本病发生的主要驱动因素,也是影响GISTs患者治疗及预后的关键因素之一.影像学检查具有无创性,可以多角度、多方位地显示肿瘤,是目前术前评估GISTs的主要方法.随着影像技术的不断发展,术前通过影像学方法对GISTs进行无创且明确的基因分型,对患者选择靶向药物和剂量及评估靶向治疗疗效起到一定积极作用.本文就GISTs基因型及靶向治疗疗效的影像学研究进展进行综述.
Abstract
Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal tract,and they are also genetically heterogeneous tumors.c-KIT gene or PDGFRA gene mutation is the main driving factor leading to its occurrence,and it is also one of the key factors affecting the treatment and prognosis of patients with GISTs.Imaging examination is non-invasive and can display tumors from multiple angles and directions,making it the main method for preoperative evaluation of GISTs.With the continuous development of imaging technology,non-invasive and definite genotyping of GISTs by imaging methods before surgery plays a positive role in the selection of targeted drugs and doses for patients and the evaluation of targeted treatment efficacy.This article reviews the imaging progress on the genotype of GISTs and the efficacy of targeted therapy.
关键词
胃肠道间质瘤/基因型/分子靶向治疗/放射学/综述Key words
Gastrointestinal stromal tumors/Genotype/Molecular targeted therapy/Radiology/Review引用本文复制引用
基金项目
兰州大学第二医院"翠英科技创新"计划(CY2021-ZD-01)
出版年
2024
NETL
NSTL
万方数据