Purpose T o analyze the characteristics of different segments of vertebral-basilar artery lesions in posterior circulation cerebral infarction(PCCI)based on CT angiography,and to study its risk factors to improve the early recognition rate.Materials and Methods A total of 199 patients with acute cerebral infarction in Beijing Friendship Hospital,Capital Medical University from January 2022 to March 2023 were enrolled,retrospectively.98 with PCCI,and 101 with anterior circulation cerebral infarction.The groups were compared for differences in vertebral artery dominance,stenosis incidence and stenosis degree in the various vertebrobasilar artery segments.A binary Logistic regression analysis was applied to identify the risk factors for PCCI.Results The rate of vertebral artery dominance(63.3%vs.48.5%)and the incidence of basilar artery stenosis(33.7%vs.20.8%)were significantly higher in the PCCI group than in the anterior circulation cerebral infarction group(x2=4.387,4.174,both P<0.05).The groups differed significantly in the degree in the vertebral artery segments V1(Z=2.029,P=0.042)and V4(Z=3.315,P=0.001)and in the basilar artery(Z=2.254,P=0.024),with a higher percentage of severe stenosis in the PCCI group.Vertebral artery dominance(OR=4.285,95%CI 1.530-12.003)and right vertebral artery V4 segment moderate to severe stenosis/occlusion(OR=5.883,95%CI 1.458-21.022;OR=5.537,95%CI 1.623-21.329)were independent risk factors for PCCI.Conclusion PCCI is related to morphological changes of the vertebrobasilar artery,right vertebral artery dominance and moderate to severe stenosis/occlusion of V4 segment of right vertebral artery have a higher risk of PCCI.