Multiple myeloma is a kind of hematological malignancy commonly seen in the elderly.Its main feature is that abnormal proliferation of bone marrow plasma cells replace normal bone marrow,which changes the water fat ratio of vertebral bone marrow,leading to bone destruction and bone marrow infiltration.At present,dual energy CT virtual non calcium and modified Dixon Quant can detect the changes of bone marrow and conduct qualitative and quantitative analysis of bone lesions,which can assist in the diagnosis of multiple myeloma,prompt treatment response and judge the prognosis of patients.This paper reviews the application progress of the above two quantitative techniques in multiple myeloma,in order to provide imaging reference for the diagnosis and treatment of multiple myeloma.