闪光放射治疗(Flash-RT)技术的研究进展
Advance on research of Flash-RT technology
戴相昆 1吴韶鹃 1王金媛 1俞伟 1杜乐辉 1阎长鑫 1张石磊 1马娜 1雷霄 1曲宝林1
作者信息
- 1. 解放军总医院第一医学中心放射治疗科 北京 100853
- 折叠
摘要
经过多年发展,精准放射治疗技术已广泛应用,但现有技术仍受限于正常组织耐受剂量的限制,无法实现肿瘤治疗的最佳目标.闪光放射治疗(Flash-RT)是一种以超高剂量率射束(UHDR)进行照射的放射治疗技术,能够在显著降低正常组织辐射损伤的同时,最大限度地治疗肿瘤.但直到目前,Flash-RT的生物学机制、关键物理参数及触发机制等尚不明确,其原理及临床转化应用仍处于研究阶段.本综述通过归纳Flash-RT相关研究,阐明Flash-RT研究的技术进展及临床转化应用.
Abstract
At present,precise radiotherapy has been widely used through the development with many years,but the existing technique still is limited by the limitation of tolerance dose of normal tissues,which cannot achieve the optimal goal of treating tumor.Flash radiotherapy(Flash-RT)is one kind of radiotherapy technique that uses the beam with ultra-high dose rate(UHDR)to conduct irradiation,which can furthest treat tumors while significantly reduce radiation injury of normal tissues.But until now,the biological mechanism,key physical parameters and triggering mechanism of Flash-RT are still unclear,and its principle and clinical translational application are still in the stage of research.This review clarified the technological advance and clinical translational application of Flash-RT research through summarized the relevant research of Flash-RT.
关键词
放射治疗/超高剂量率/闪光放射治疗(Flash-RT)Key words
Radiotherapy/Ultra-high dose rate/Flash radiotherapy(Flash-RT)引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据