闪光放射治疗(Flash-RT)在肿瘤治疗中的研究进展
Research advance of Flash-RT in tumor treatment
王源 1杜乐辉 1张沛 1商庆超 1郭兴东 1卢江岳 1雷霄 1曲宝林1
作者信息
- 1. 解放军总医院第一医学中心放射治疗科 北京 100853
- 折叠
摘要
闪光放射治疗(Flash-RT)作为放射治疗技术基础领域的关键性突破,可能引起放疗领域新的大变革.本文综述了Flash-RT在肿瘤治疗中应用和机制探索的最新研究进展.目前研究发现无论是电子束和光子Flash-RT还是质子Flash-RT相较于常规剂量率放疗均可以降低对正常组织的损伤,但相关机制还未明确,包括但不限于氧耗竭、DNA损伤、细胞衰老、凋亡和免疫反应等.Flash-RT在肿瘤组织与正常组织损伤间的差异进一步减少了放疗的局限性,相较于常规放疗减少了不良反应和并发症,具有广阔应用前景.
Abstract
The Flash radiotherapy(Flash-RT),which is the key breakthrough in the basic field of radiotherapy technique,which is expected to cause a new major transformation in the field of radiotherapy.In this paper,we reviewed the latest research advances of the application and the mechanism exploration of Flash-RT in tumor treatment.Current studies have found that both the Flash-RT with electron beams and photon and the Flash-RT with proton can reduce injury of normal tissue than radiotherapy with conventional dose-rate,but the relevant mechanisms are not yet clearly understood,which includes but not limited to oxygen depletion,DNA damage,cellular senescence,apoptosis and immune response.The difference of Flash-RT injury between tumor tissue and normal tissue further reduces the limitations of radiotherapy,and reduces the adverse reaction and complication compared with conventional radiotherapy,which has wide application prospects.
关键词
闪光放射治疗(Flash-RT)/超高剂量率/肿瘤治疗/机制Key words
Flash radiotherapy(Flash-RT)/Ultra-high dose rate/Tumor treatment/Mechanism引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据