摘要
目的:探究与分析多导睡眠监测仪在精神分裂症患者中的应用及其对睡眠质量和结构的监测效果.方法:选取2021年3月至2023年5月新疆医科大学第一附属医院收治的90例精神分裂症患者作为观察组,同时选择80名健康志愿者作为健康对照组,所有受试者均采用多导睡眠监测仪进行睡眠监测,对比两组匹兹堡睡眠质量指数(PSQI)评分、多导睡眠监测仪睡眠质量指标、睡眠结构指标、纺锤波指标;同时Pearson相关性分析探讨PSQI评分与睡眠参数的相关性.结果:健康对照组PSQI评分为(5.36±0.65)分,观察组PSQI评分为(14.24±3.58)分,观察组PSQI评分高于健康对照组,差异有统计学意义(t=23.115,P＜0.05).观察组与健康对照组相比,睡眠总时间较短、睡眠潜伏期较长、快速动眼期(REM)较短以及觉醒次数较多,差异均有统计学意义(t=15.136、40.355、36.620、24.226,P＜0.05).观察组治疗前与健康对照组的REM潜伏期比较,差异无统计学意义(P＞0.05).观察组治疗后与观察组治疗前相比睡眠总时间较长、睡眠潜伏期较短、REM期较长、觉醒次数较少,差异均有统计学意义(t=3.145、12.021、8.668、9.101,P＜0.05),观察组治疗后与健康对照组相比睡眠总时间较短、睡眠潜伏期较长、REM期较短、觉醒次数较多,差异均有统计学意义(t=9.704、14.781、15.899、9.901,P＜0.05).健康对照组与观察组治疗前相比,N1%值较高、N2%值较高及N3%值较低,差异有统计学意义(t=10.163、9.483、10.065,P＜0.05).健康对照组与观察组治疗前、治疗后的REM%比较,差异均无统计学意义(P>0.05).观察组治疗后与治疗前相比N1%值较低、N2%值较低、N3%值较高(t=10.163、9.483、10.065,P＜0.05),治疗后与健康对照组相比N1%值较高、N2%值较高、N3%值较低,差异均有统计学意义(t=7.628、4.210、7.153,P＜0.05).观察组治疗后与治疗前相比纺锤波密度、振幅和时间均较高,观察组治疗后与健康对照组相比,纺锤波密度较低、振幅较低、时间较短,差异有统计学意义(t=2.514、2.665、2.014,P＜0.05).Pearson相关性分析显示,PSQI评分分别与睡眠总时间、REM期、N3%、纺锤波密度及纺锤波振幅呈现出了明显的负相关性,与睡眠潜伏期、觉醒次数、N1%、N2%呈现了明显的正相关性(r=-0.612、-0.269、-0.812、-0.778、-0.841;r=0.382、0.226、0.654、0.778,P＜0.05).结论:实施多导睡眠监测仪监测可观察到精神分裂症患者存在睡眠质量及结构异常的表现,且睡眠纺锤波的活性也呈现出了异常的表现,其指标与PSQI之间具有密切的关系.
Abstract
Objective:To explore and analyze the application of polysomnographic sleep monitor in patients with schizophrenia and the monitoring effect of that on sleep quality and sleep structure of them.Methods:A total of 90 patients with schizophrenia admitted to the First Affiliated Hospital of Xinjiang Medical University from March 2021 to May 2023 were selected as the observation group,and 80 healthy volunteers were selected as the health control group.All subjects were monitored by polysomnographic sleep monitor.Pittsburgh Sleep Quality Index(PSQI)score,sleep quality index of polysomnographic sleep monitor,the indicators of sleep structure and spindle wave index between two groups were compared.At the same time,Pearson correlation analysis was used to explore the correlation between PSQI score and sleep parameters.Results:PSQI score of the health control group was(5.36±0.65)scores,and that of the observation group was(14.24±3.58)scores,and the PSQI score of the observation group was significantly higher than that of the health control group,and the difference was statistically significant(t=23.115,P<0.05).Compared with the health control group,the observation group had shorter total sleep time,longer sleep latency,shorter rapid eye movement(REM)period and more awakening times,with statistical significances(t=15.136,40.355,36.620,24.226,P<0.05),respectively.There was no significant difference in REM latency between the observation group and the control group before treatment(P>0.05).Compared with the observation group before treatment,the observation group after treatment had longer total sleep time,shorter sleep latency,longer REM period and less awakening times,with statistical significances(t=3.145,12.021,8.668,9.101,P<0.05),respectively.Compared with health control group after treatment,the observation group after treatment had shorter total sleep time,longer sleep latency,shorter REM period and more awakening times,and the differences of them between two groups were statistically significant(t=9.704,14.781,15.899,9.901,P<0.05).Compared with the observation group before treatment,the N1%value was higher,the N2%value was higher and the N3%value was lower in the health control group before treatment,and the differences were statistically significant(t=10.163,9.483,10.065,P<0.05),respectively.There were no significant differences in REM%between the health control group and the observation group before and after treatment(P>0.05),respectively.Compared with the observation group before treatment,that after treatment had lower N1%value and N2%value,and higher N3%value(t=10.163,9.483,10.065,P<0.05),respectively.Compared with the health control group after treatment,the observation group after treatment had higher N1%value and N2%value,and lower N3%value,and the differences of them between two groups were statistically significant(t=7.628,4.210,7.153,P<0.05),respectively.Compared with the observation group before treatment,that after treatment had higher spindle wave density,amplitude and time.Compared with the health control group after treatment,the observation group after treatment had lower spindle wave density,amplitude and time,and the differences of them between two groups were significant(t=2.514,2.665,2.014,P<0.05),respectively.Pearson correlation analysis showed that PSQI score appeared significantly negative correlation with total sleep time,REM period,N3%value,spindle wave density and spindle amplitude,and appeared significantly positive correlation with sleep latency,awakening times,N1%value and N2%value,respectively,and the differences were statistically significant(r=-0.612,-0.269,-0.812,-0.778,-0.841,r=0.382,0.226,0.654,0.778,P<0.05).Conclusion:Abnormal sleep quality and structure,as well as abnormal sleep spindle wave activity,of patients with schizophrenia can be observed by using polysomnographic sleep monitor,which indicators is closely related to PSQI.
基金项目
新疆维吾尔自治区科技支疆项目(指令性项目)(2022E02055)
国家科技期刊平台
NSTL
万方数据