Objective:To explore the correlations among contrast-enhanced ultrasound(CEUS)enhancement,time to peak and resolution time,and pathological grading and alpha fetoprotein(AFP)in diagnosing hepatocellular carcinoma(HCC),so as to provide scientific basis for the CEUS application.Methods:A total of 350 HCC patients who admitted to Kailuan General Hospital of Tangshan City,Hebei Province from June 2018 to February 2020 were selected.All patients underwent routine CEUS scanning and AFP detection that was performed by using Roche e411 electrochemiluminescence immunoassay analyzer.Using World Health Organization(WHO)Category Classification and Diagnostic Criteria Series to complete grading for liver cancer.The COX regression analysis was adopted to analyze the correlation between CEUS characteristic parameters and age,AFP,tumor grading,tumor size and gender.Results:The diameter of liver nodules of 304 HCC patients ranged from 9.0 to 146.2 mm,which maximum average diameter was 42.5 mm.The COX analysis indicated that serum AFP level was important influencing factor on CEUS examination results at arterial phase(HR=1.83,P<0.05).The blood supply artery within the tumor appeared positive correlation with serum AFP level,and the tumor size appeared positive correlation with the CEUS enhancement at arterial phase(r=0.231,0.483,P<0.05),and the correlation between CEUS enhancement at arterial phase and tumor size was strongest.Conclusion:The serum AFP level is correlated with the measured results of CEUS enhancement at arterial phase,time to peak and resolution time,which expression level is often influenced by some factors such as serum AFP and tumor size.It can provide reference for subsequent diagnosis and treatment.
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