彩色多普勒超声与miR-19a和miR-210在颈动脉狭窄中的应用价值
Application value of color Doppler ultrasound,miR-19a and miR-210 in carotid artery stenosis
张昊 1王晖 2徐锋 2张书研 3温永飞 2王智培 1段朋仓4
作者信息
- 1. 沧州市人民医院超声科 沧州 061000
- 2. 沧州市人民医院呼吸与危重症医学科 沧州 061000
- 3. 沧州市人民医院心内二科 沧州 061000
- 4. 沧州市人民医院神经内科 沧州 061000
- 折叠
摘要
目的:分析彩色多普勒超声与微小核糖核酸(miRNA)-19a(miR-19a和miR-210)在颈动脉狭窄中的应用价值.方法:选取2020年10月至2022年10月在沧州市人民医院诊治的102例颈动脉狭窄患者纳入病例组,另选取同期在医院体检需行彩色多普勒超声检查的102名健康体检者纳入健康对照组.病例组均在入院1周内行彩色多普勒超声检查和数字减影血管造影(DSA)检查,两组均行血清指标检测.比较两组miR-19a、miR-210,以及病例组不同狭窄程度miR-19a、miR-210,分析彩色多普勒超声与miR-19a、miR-210及其联合对颈动脉狭窄的诊断价值.结果:病例组102例患者经彩色多普查超声颈总动脉检测,正常15例,轻度狭窄15例,中度狭窄21例,重度狭窄33例,完全闭塞18例.病例组miR-19a明显高于健康对照组,miR-210明显较低于对照组,差异有统计学意义(t=10.755、-5.903,P＜0.05).病例组不同狭窄程度miR-19a比较:轻度狭窄＜中度狭窄＜重度狭窄＜完全闭塞,miR-210比较:轻度狭窄＞中度狭窄＞重度狭窄＞完全闭塞,差异均有统计学意义(F=160.399、147.462,P＜0.05).受试者工作特征(ROC)曲线分析显示,彩色多普勒超声、miR-19a及miR-210联合诊断颈动脉狭窄的ROC曲线下面积(AUC)分别为0.892、0.842、0.729和0.978,联合诊断的灵敏度为97.1%,特异度为95.1%.结论:彩色多普勒超声与miR-19a、miR-210联合对颈动脉狭窄具有较高的诊断价值.
Abstract
Objective:To analyze the application value of color Doppler ultrasound,microribonucleic acid-19a(miR-19a)and miR-210 in carotid artery stenosis.Methods:A total of 102 patients with carotid artery stenosis who were diagnosed and treated in Cangzhou People's Hospital from October 2020 to October 2022 were selected as the research group,and 102 health persons who underwent color Doppler ultrasound of physical examination in hospital at the same period were selected as the health control group.Both two groups underwent color Doppler ultrasound examination and digital subtraction angiography(DSA)within one week after admitted to hospital.The miR-19a and miR-210 between the two groups were compared,and the miR-19a and miR-210 of patients with different stenosis degrees of research group also were compared.And then,the diagnostic values of color Doppler,miR-19a,miR-210 and the combination of them were analyzed in diagnosing carotid artery stenosis.Results:The results of color Doppler ultrasound in detecting common carotid artery 102 patients of research group indicated that 15 cases were normal,and 15 cases occurred mild stenosis,and 21 cases occurred moderate stenosis,and 21 cases occurred severe stenosis and 33 cases occurred complete occlusion.The miR-19a of the research group was significantly higher than that of the health control group,and the miR-210 of the research group was significantly lower than that of the health control group(t=10.755,-5.903,P<0.05).The miR-19a results of the research group indicated that the miR-19a of mild stenosis<that of moderate stenosis<severe stenosis<complete occlusion,and the miR-210 results of the research group indicated that the miR-210 of mild stenosis>that of moderate stenosis>severe stenosis>complete occlusion,and the differences were statistical significant(F=160.399,147.462,P<0.05),respectively.The receiver operating characteristic(ROC)curve analysis showed that the area under curve(AUC)values of color Doppler ultrasound,miR-19a,miR-210 and combined diagnosis of them for carotid artery stenosis were respectively 0.892,0.842,0.729 and 0.978,and the sensitivity and specificity of the combined diagnosis were respectively 97.1%and 95.1%.Conclusion:The combined diagnosis of color Doppler ultrasound,miR-19a and miR-210 has higher diagnostic value for carotid artery stenosis.
关键词
彩色多普勒超声/微小核糖核酸(miRNA)-19a(miR-19a)/miR-210/颈动脉狭窄/应用价值Key words
Color Doppler ultrasound/Microribonucleic acid-19a(miR19a)/Microribonucleic acid-210(miR-210)/Carotid stenosis/Application value引用本文复制引用
基金项目
河北省卫生健康委项目(20211564)
沧州市科技局项目(222106111)
出版年
2024
国家科技期刊平台
NSTL
万方数据