基于拉曼光谱的无创血糖测量设备的研究
Research on noninvasive equipment of measuring blood glucose on the basis of Raman spectrum
丁远彤 1丁贤根 1白晓苏 1丁文1
作者信息
- 1. 港湾之星健康生物(深圳)有限公司 深圳 518183
- 折叠
摘要
目的:研究设计一种基于拉曼光谱的无创血糖测量设备,以实现无创血糖的精准检测.方法:分析研究业内现有的基于拉曼光谱的血糖检测设备验证成果,针对性设计整机专用的拉曼光路和硬件电路.拉曼光路包括一次光路和二次光路,其中一次光路分析设计同轴模式和离轴模式;二次光路分析设计滤光镜、狭缝、光栅分光镜和光谱积分模块.硬件电路整合激光器控制模块、光谱仪积分模块和总控制模块,最终构成高灵敏度的拉曼光谱定量监测血糖含量的专用设备.选取深圳某三甲医院和社区康复中心就诊人员中的312名志愿者,采用生化仪与无创血糖测量设备进行对比测试.结果:研究设计的基于拉曼光谱的无创血糖测量设备实现了采用拉曼光谱在手指指腹进行无创检测血糖的功能,完成了整机产品化设计,并可大幅度降低无创血糖测量设备制造成本.在对312名志愿者的无创血糖测量设备与生化仪对比测试中,其检测误差＜10%.结论:本研究研制的无创血糖测量设备,通过扩大检测数量和软件迭代,能够实现无创血糖的精准检测.
Abstract
Objective:To study and design a new noninvasive equipment of measuring blood glucose on the basis of Raman spectrum,so as to realize noninvasively precise detection for blood glucose.Methods:This research specifically designed a dedicated Raman optical path and hardware circuit for entire machine through analyze and research the verification achievements of blood glucose measure equipment based on Raman spectrum.The Raman optical path included primary and secondary optical paths.The analysis of primary optical path was designed for both coaxial and off-axis modes,while the analysis of secondary optical path was designed with filters,slits,grating beam splitters and spectral integration modules.The hardware circuit integrated laser control module,spectrometer integration modules and general control modules.The above modules finally constituted special equipment with high sensitivity,which monitored the content of blood glucose by Raman spectrum.A total of 312 volunteers,who admitted to a Third-level grade-A hospital,were selected,and the biochemical analyzer and the noninvasive equipment of measuring blood glucose were adopted to conduct comparative test.Results:This researched noninvasive equipment of measuring blood glucose on the basis of Raman spectrum realized the function that detected blood glucose on finger belly by using Raman spectrum,which completed the product design for entire machine,and it can significantly reduce manufacturing cost of the noninvasive equipment of measuring blood glucose.In the comparative test for the 312 volunteers between noninvasive equipment of measuring blood glucose and biochemical analyzer,the detection error was less than 10%.Conclusion:The researched noninvasive equipment of measuring blood glucose can realize noninvasively precise detection for blood glucose through expands the number of test and iteration of software.
关键词
拉曼光谱/特征峰/血液葡萄糖含量/无创血糖检测/设备硬件设计Key words
Raman spectrum/Characteristic peak/Blood glucose content/Noninvasive monitoring for blood glucose/Hardware design of equipment引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据