摘要
目的:探讨高压氧舱治疗对脑损伤后遗症患者的康复效果.方法:选取2023年1月至2024年1月期间新疆医科大学第一附属医院收治的80例脑损伤后遗症患者,依据随机数表法将其分为对照组和观察组,每组40例,对照组接受常规治疗和干预,观察组在常规治疗和干预基础上联合高压氧舱治疗,评价两组患者血清氧化应激指标、神经营养因子指标水平,以及神经功能、认知功能、运动功能及生存质量.结果:治疗后观察组血清氧化应激指标中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、基质金属蛋白酶9(MMP-9)及活性氧(ROS)水平均低于对照组,差异有统计学意义(t=5.578、11.065、3.706,P＜0.05),神经营养因子泛素羧基末端水解酶L1(UCH-L1)、神经元特异烯醇化酶(NSE)以及血清钙结合蛋白(S100-β)水平均低于对照组,血清氧化应激指标脑氧摄取率(CERO2)高于对照组,差异有统计学意义(t=5.170、4.277、4.130、2.260,P＜0.05);治疗后观察组美国国立卫生研究院卒中量表(NIHSS)评分低于对照组,精神状况评价量表(MMSE)评分高于对照组,差异有统计学意义(t=15.874、7.820,P＜0.05);Loewenstein认知功能评定量表(LOTCA)、简化Fugl-Meyer运动功能量表(FMA)上、下肢评分均高于对照组,差异有统计学意义(t=14.051、4.766、8.622,P＜0.05);世卫组织生存质量表(WHOQOL-BREF)中生理、心理、社会及环境评分均高于对照组,差异有统计学意义(t=19.968、21.979、18.077、19.695,P＜0.05).结论:脑损伤后遗症患者应用高压氧舱治疗,利于调整血清氧化应激指标、神经营养因子指标水平,可改善神经功能缺损,促进认知及运动功能恢复,提升生存质量.
Abstract
Objective:To explore rehabilitation effect of hyperbaric oxygen chamber treatment on patients with sequelae of brain injury.Methods:From January 2023 to January 2024,a total of 80 patients with sequelae of brain injury were selected from The First Affiliated Hospital of Xinjiang Medical University,and they were randomly divided into control group and observation group,with 40 patients in each group.The control group received conventional treatment and intervention,while the observation group was treated with hyperbaric oxygen chamber on the basis of the conventional treatment and intervention of control group.The levels of serum oxidative stress indicators,neurotrophic factor indicator,as well as neurological function,cognitive function,motor function and quality of life of the two groups were evaluated.Results:After treatment,the levels of serum oxidative stress indicators such as neutrophil gelatinase-related lipocalin(NGAL),matrix metalloproteinase-9(MMP-9),reactive oxygen species(ROS)of observation group were significantly higher than those of control group(t=5.578,11.065,3.706,P<0.05),respectively,and the ubiquitin carboxy-terminal hydrolase L1(UCH-L1)of neurotrophic factor,neuron-specific enolase(NSE)and serum calcium-binding protein(S100-β)of observation group were significantly lower than those of control group,while cerebral extraction rate of oxygen(CERO2)of serum oxidative stress indicators of observation group was significant higher than that of control group,and the differences of them were significantly(t=5.170,4.277,4.130,2.260,P<0.05),respectively.After treatment,the score of National Institutes of Health Stroke Scale(NIHSS)of observation group was lower than that of control group,and the score of Mini-Mental State Examination(MMSE)of observation group was significantly higher than that of control group,and the differences of them were statistical significance(t=15.874,7.820,P<0.05),respectively.In additions,the scores of Loewenstein Occupational Therapy Cognitive Assessment(LOTCA),Simplified Fugl-Meyer Assessment(FMA)upper and lower limbs of observation group were significantly higher than those of control group,and the differences of them between two groups were significant(t=14.051,4.766,8.622,P<0.05),respectively.The scores of physiological,psychological,social and environment factor of World Health Oganization Quality of Life Scale(WHOQOL-BREF)in observation group were higher than those in control group,and the differences of them between two groups were statistically significant(t=19.968,21.979,18.077,19.695,P<0.05).Conclusion:The application of hyperbaric oxygen chamber in patients with sequelae of brain injury is beneficial to adjust the levels of serum oxidative stress indicator and neurotrophic factor indicator,which can improve the deficit of neurological function,and promote the recovery of cognitive and motor functions,and improve the quality of life.
基金项目
省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2020-KS9)
维普
万方数据