Objective:To investigate the relationship between image quality and radiation dose in axial scan and spiral scan of coronary computed tomography angiography (CCTA). Methods:A total of 60 patients who underwent CCTA in Beijing Friendship Hospital of Capital Medical University from July 2021 to January 2022 were selected,and they were divided into an axial scan group and a spiral scan group,with 30 cases in each group. The image quality,radiation dose,average heart rate during the examination,diagnostic value for moderate and severe coronary stenosis (degree≥50%) and patients' satisfaction of two kinds of modes were analyzed. Results:The excellent rates of image quality of axial scan group and spiral scan group were respectively 96.67% (29/30) and 93.33% (28/30),without significant differences (P>0.05). The dose-length product (DLP),computed tomography dose index of volume (CTDIvol) and effective dose (ED) in the axial scan group were significantly lower than those in the spiral scan group (t=180.637,30.945,368.414,P<0.05),respectively. There were no statistically significant differences in the average heart rate,DLP and ED under different heart rate between the two groups during the examination process (P>0.05). The examination of digital subtraction angiography was used as "gold standard",and the diagnostic sensitivity,specificity,accuracy,positively predictive value and negatively predictive value in the axial scan group were significantly higher than those in the spiral scan group (x2=11.140,12.830,13.340,9.350,14.450,P<0.05),respectively. The satisfaction degree of service effect of patients in axial scan group was 93.33% (28/30) for examination mode of CCTA imaging,which was significantly higher than that of spiral scan group,and the difference was significant(x2=5.455,P<0.05). Conclusion:The objective assessment,diagnostic value and patient's satisfaction of image quality of axial scan of CCTA are higher than those of spiral scan mode,which radiation dose is lower than that of spiral scan mode. CCTA should choose reasonable scan mode according to heart rate and degree of coronary artery stenosis,and other,actual condition of patients.