Objective:To compare the difference of tumor control probability (TCP) and normal tissue complication probability (NTCP) between different radiotherapy schemes bases on biological model of non-small cell lung cancer(NSCLC) that used in assessing radiotherapy. Methods:The radiotherapy data of 15 NSCLC patients who admitted to Tianjin Medical University General Hospital from April 2021 to July 2022 were collected. The low resolution Poisson (TCP Poisson LQ) model,Zaider Minerbo (TCP-ZM) model and TCP Logit model were respectively adopted to fit TCP curve for all patients. Lyman-Kutcher-Burman (LKB) model and linear quadratic (LQ) model were adopted to fit NTCP curves for comparing applicability of several models in tumor control rate,radiation pneumonitis and radiation pericarditis,and the differences in TCP and NTCP among conventional radiotherapy regimen (scheme 1),regimen of maximum gain ratio of treatment (scheme 2),and maximum segmentation frequency regimen (scheme 3) as mean lung dose (MLD)<20 Gy. Results:The average TCP of the TCP Poisson LQ model was (87.2±11.92)％ at 60-70 Gy,which met the requirement of clinical dose. The incidence rate of radiation pneumonitis,which was calculated by the NTCP-LQ model,was higher than that by the NTCP-LKB model when the average radiation dose of whole lung was less than 26 Gy. In the comparison of different schemes,the TCP mean of scheme 3 was (81.56±11.20)％,which was respectively higher than that of other two schemes (60.28±8.04)％ and (69.46±18.09)％,and the differences of them were statistically significant (t=-6.196,-1.969,P<0.05). The average incidence of radiation pneumonitis in Scheme 3 was (19.24±0.43)％,which was respectively higher than that in Scheme 1 and Scheme 2[(15.07±3.24)％ and (15.89±4.55)％],respectively,and the differences of them were statistically significant (t=-5.878,-2.386,P<0.05). Conclusion:It is reasonable to use Poisson-LQ model and NTCP-LQ model to calculate TCP,and incidence of radiation pneumonitis in NSCLC patients. The maximum segmentation frequency scheme (Scheme 3) can effectively improve TCP under the premise of ensuring treatment safety when MLD<20 Gy.
Non-small cell lung cancer (NSCLC)Radiobiological modelTumor control probability (TCP)Normal tissue complication probability (NTCP)
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