Objective:To investigate the short-term efficacy and safety of three dimensional (3D) brachytherapy with 192Ir under computed tomography (CT)-guidance in patients with locally advanced cervical carcinoma. Methods:A total of 82 patients with locally advanced cervical carcinoma,who admitted to the Department of Tumor Radiotherapy of the First Affiliated Hospital of Xi 'an Jiaotong University from October 2022 to October 2023,were selected,and they were divided into observation group and control group according to random number table method,with 41 cases in each group. The observation group received 3D brachytherapy with 192Ir under computed tomography (CT)-guidance,and control group received routine two-dimensional (2D) brachytherapy. The short-term efficacy,serum tumor markers,treatment safety and quality of life of the two groups were compared. Results:In observation group,the total effective rate was 97.56％,which was significantly higher than 80.49％ in control group (x2=6.116,P<0.05). The levels of glucose chain antigen 125 (CA125) and squamous cell carcinoma (SCC) antigen of serum tumor markers after treatment of observation group were significantly lower than those of control group (t=11.352,5.507,P<0.05),respectively. The incidences of radiation proctitis and radiation cystitis of observation group were respectively 7.32％ and 4.88％,which were significantly lower than 24.39％ and 21.95％ of control group (x2=4.479,5.143,P<0.05),respectively. After treatment,the scores of functional assessment of cancer therapy-cervix (FACT-Cx) scale (physiological status,social/family status,emotional status,functional status and additional concerns) of observation group were significantly higher than those of control group,and the differences of them between two groups were significantly (t=6.150,7426,9.341,10.029,8.623,P<0.05),respectively. Conclusion:3D brachytherapy with 192Ir under CT-guidance can achieve favorable short-term efficacy and higher safety on patients with locally advanced cervical carcinoma,which is helpful to further improve the quality of life of patients.
维普
万方数据
