Prediction of the changes of the parameters of cardiac function of ultrasound monitoring and SENP-1/HIF-1α pathway for curative effect of patients with OSAHS complicated with cardiovascular and cerebrovascular diseases
Objective:To investigate the relationship between the cardiac function parameters of ultrasound monitoring and the expression level of serum sentrin/SUMO-specific protease1 (SENP-1)/hypoxia-inducible factor 1 alpha (HIF-1α) pathway,and the predictive value of them on curative effect on patients with obstructive sleep apnea hypopnea syndrome (OSAHS) complicated with cardiovascular and cerebrovascular diseases. Methods:A total of 100 patients with OSAHS complicated with cardiovascular and cerebrovascular diseases,who admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2021 to June 2023,were selected as the study objects,and all of them were treated with continuous positive airway pressure (CPAP). According to the treatment effect,they were divided into effective group (n=65) and ineffective group (n=35). The ultrasound was adopted to measure the parameters of cardiac function,and the Enzyme linked immunosorbent assay (ELISA) was used to measure expression levels of SENP-1/HIF-1α pathway. The parameters of cardiac function and the expression levels of SENP-1/HIF-1α pathway of two groups between before and after treatment were compared. The Pearman analysis was adopted to analyze the correlation between the parameters of cardiac function and the levels of SENP-1/HIF-1α pathway before treatment. The receiver operating characteristic (ROC) curve was drawn to assess the predictive efficacy of single pre-treatment parameters of cardiac function,single SENP-1/HIF-1α pathway and the combined detection of them on the curative effect of patients with OSAHS complicated with cardiovascular and cerebrovascular diseases. Results:The left ventricular end-diastolic diameter (LVEDD),left ventricular end-systolic diameter (LVESD) and the index of myocardial work (Tei) of effective group after treatment were significantly lower than those before treatment,and those indicators of effective group were significantly lower than them of ineffective group (t=4.257,3.400,5.454,P<0.05),respectively. The LVEF,LVFS and ratio of early peak velocity (E) of blood flow to late peak velocity (A) of blood flow (E/A) of mitral valve in the effective group after treatment were significantly higher than those before treatment,and these indicators of effective group were significantly higher than those of ineffective group (t=4.517,2.280,4.952,P<0.05),respectively. Serum SENP-1 and HIF-1α levels in the effective group after treatment were significantly lower than those before treatment,and these indicators of effective group were significantly lower than those of ineffective group (t=2.648,4.520,P<0.05),respectively. Pearman correlation analysis showed that LVEDD,LVESD and Tei index were positively correlated with SENP-1 (r=0.523,0.572,0.513,P<0.05),and were negatively correlated with SENP-1/HIF-1α(r=-0.508,-0.411,-0.479,P<0.05),respectively. The LVEF,LVFS and E/A were positively correlated with HIF-1α (r=0.453,0.511,0.426,P<0.05),and LVEF,LVFS and E/A were negatively correlated with SENP-1/HIF-1α (r=-0.489,-0.479,-0.421,P<0.05),respectively. The area under curve (AUC) value of the combined detection of the parameters of cardiac function and serum SENP-1/HIF-1α pathway in predicting the curative effect of patients with OSAHS complicated with cardiovascular and cerebrovascular diseases was 0.909 (95％CI:0.843～0.975). Conclusion:The combined detection of the parameters of cardiac function of ultrasonic determination and SENP-1/HIF-1α pathway has higher predictive value for the curative effect of patients with OSAHS complicated with cardiovascular and cerebrovascular diseases.
维普
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