Predictive value of combined detection of inner diameter of yolk sac,coagulation indicators and sHLA-G on pregnancy outcome of patients with threatened abortion after tocolysis
Objective:To analyze the predictive value of combined detection of color ultrasound parameters,coagulation indicators and soluble leukocyte antigen G (sHLA-G) on pregnancy outcomes of patients with threatened abortion after tocolysis. Methods:A total of 100 patients,who met the diagnostic condition of threatened abortion and admitted to Dongguan People's Hospital Xiegang Branch between January 2019 and January 2021,were selected. They were divided into success group and failure group according to pregnancy outcomes after tocolysis,with 50 cases in each group. The color ultrasound parameters,coagulation indicators and sHLA-G levels were measured,and logistic regression and receiver operating characteristic (ROC) curve were used to analyze predictive value of the above indicators on the pregnancy outcomes of patients with threatened abortion after tocolysis. Results:The inner diameter of the yolk sac (5.37±1.02) ml and sHLA-G level (65.37±12.38)U/ml in success group were significantly higher than yolk sac and sHLA-G level in failure group,and the differences were statistically significant (t=12.566,19.989,P<0.05),respectively. The resistance index (RI) and D-dimer (D-D) levels of success group were significantly lower than those of failure group,and the differences were statistically significant (t=20.344,17.603,P<0.05),respectively. The inner diameter of the yolk sac,RI,D-D and sHLA-G were risk factors that affected the pregnancy outcome of patients with threatened abortion after tocolysis (OR=2.349,2.115,2.266,2.21,P<0.05),respectively. The sensitivity,specificity,accuracy and area under curve (AUC) of the combined detection of inner diameter of yolk sac,RI,D-D and sHLA-G in predicting pregnancy outcomes of patients with threatened abortion after tocolysis were 96.00％,98.00％,97.00％ and 0.991,respectively,which were significantly higher than those of the singly each indicator (t=2.514,3.628,4.258,6.134,P<0.05). Conclusion:The combined detection of inner diameter of yolk sac,coagulation indicators and sHLA-G has predictive value for the pregnancy outcomes of patients with threatened abortion after tocolysis. Moreover,the combined detection of inner diameter of yolk sac,RI,D-D and sHLA-G levels can significantly improve the sensitivity,specificity and accuracy of prediction.
Yolk sacCoagulation indicatorSoluble leukocyte antigen G (sHLA-G)Threatened abortionTocolysisPregnancy outcome
维普
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