具备溶酶体逃逸功能材料的研究进展
Materials with Lysosomal Escape Function and Its Mechanism
严米娜 1赵春顺2
作者信息
- 1. 中山大学药学院药剂学与制药工程实验室,广州510006;沈阳药科大学药剂教研室,沈阳110016
- 2. 中山大学药学院药剂学与制药工程实验室,广州510006
- 折叠
摘要
目的 综述具备溶酶体逃逸功能的载体材料及其逃逸机制.方法 以近年来研究文献为基础,对具备溶酶体逃逸功能的载体材料的结构特点、起效机制等进行综述.结果 将具有溶酶体逃逸功能的材料进行归类,按其逃逸机制可分为2类:一类是通过提高溶酶体内的渗透压,使溶酶体破裂;另一类是加入具有膜融合功能的材料,降低溶酶体膜的稳定性.结论 对于具备溶酶体逃逸功能的载体材料的机制研究仍处于起步阶段,需要进行更深入的探讨,从而促进其研究发展.
Abstract
OBJECTIVE To review the progress on materials with lysosomal escape function.METHODS Based on the original researches in recent years,the structure properties and escape mechanism of materials with lysosomal escape function were introduced in the present paper.RESULTS The materials which can help the drug/gene to get out of the lysosomes were summarized and classified into two groups in the accordance with their escape mechanism: breaking the lysosomes by raising the osmotic pressure or destabilizing the membrane structure of lysosomes.CONCLUSION The materials with lysosomal escape function,as a novel drug delivery tool,has promising application for the delivery of drug/gene and need to be studied deeply before the materials get widely applied.
关键词
溶酶体逃逸/膜融合/质子海绵效应Key words
lysosomal escape/membrane fusion/proton sponge effect引用本文复制引用
基金项目
国家自然科学基金资助项目(81173003/H3008)
出版年
2014
NETL
NSTL
维普
万方数据