Chemical Constituents from Aqueous Extract of Carthamus tinctorius
OBJECTIVE To study the chemical constituents of the aqueousextract of Carthamus tinctorius.METHODS Compounds were isolated by a combination of various chromatographic techniques including column chromatography on macroporous resin and Sephadex LH-20 and reversed-phase HPLC.Their structures were elucidated by physiochemical properties and spectral analysis.RESULTS Twelve compounds were isolated and identified as(2E,8E)-12R-tetradecadiene-4,6-diyne-1,12,14-triol(1),(8Z)-decaene-4,6-diyn-1-O-β-D-glucopyranoside (2),(8E)-decaene-4,6-diyn-1-O-β-D-glucopyranoside (3),(2S)-4',5,6,7-tetrahydroxyflavavone 6-O-β-D-glucoside (4),p-hydroxybenzoic acid (5),3-hydroxy-4-methoxybenzoic acid (6),dihydrophaseic acid methyl ester-3-O-β-D-glucoside (7),dihydrophaseic acid methyl ester(8),4-hydroxy benzaldehyde(9),N,N'-dicoumaroyl-putrescine (10),4-(4'-hydroxyphenyl)but-3-en-2-one(11) and4-hydroxyacetophenone(12).CONCLUSION Compounds 1,3-4,6,8,and 10 are isolated from this plant for the first time.The absolute configuration and 13C-NMR data of compound 1 are for the first time reported.
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