羊耳蒜化学成分的研究
Chemical Constituents from Liparis japonica
宋仕鹏 1江凡 1李春晖 1魏婷 1余逸菲 1田新慧1
作者信息
- 1. 上海中医药大学交叉科学研究院,上海201203
- 折叠
摘要
目的 研究羊耳蒜(Liparis japonica)全草的化学成分.方法 采用硅胶、ODS、Sephadex LH-20等柱色谱进行分离纯化,通过波谱学方法及与文献对照鉴定化合物结构.结果 分离得到18个化合物,分别鉴定为acortatarin A(1),3β-hydroxy-5α,8α-epidioxyergosta-6,22-diene(2),13-epicupressic acid(3),3β-hydroxyolean-12-en-28-oic acid(4),白桦脂酸(5),gigantol(6),(2S)-3-O-octadeca-9Z,12Z,15 Z-trienoylglyceryl-O-β-D-galactopyranoside(7),α-linolenic acid(8),hydroxydihydrobovolide(5-hydroxyl-3,4-dimethy-5-penty-12(5H)-furanone)(9),反式对羟基肉桂酸(10),(+)-丁香脂素(ll),β-谷甾醇(12),2,5-.二-羟基-4-甲氧基-9,10-二氢菲(13),2,7-二羟基-3,4-二甲氧基菲(14),moscatin(15),山药素Ⅲ(16),亚油酸(17)和对羟基苯甲醛(18).结论 本实验首次从羊耳蒜属植物中分离得到结构独特的含吗啉片段的螺环生物碱,化合物2～11为首次从该属植物中分离得到.
Abstract
OBJECTIVE To study the chemical constituents of the whole herb of Liparis japonica.METHODS The compounds were isolated by column chromatography on silica gel,ODS and Sephadex LH-20 columns.Their structures were identified by analysis of physical and spectroscopic data and confirmed by comparison of their spectral data with those in the literature.RESULTS Eighteen compounds were isolated and identified respectively as acortatarin A (1),3β-hydroxy-5α,8α-epidioxyergosta-6,22-diene (2),13-epicupressic acid (3),3β-hydroxyolean-12-en-28-oic acid (4),betulinic acid (5),gigantol (6),(2S)-3-0-octadeca-9Z,12Z,15 Z-trienoylglyceryl-0-β-D-galactopyranoside (7),linolenic acid (8),hydroxydihydrobovolide (5-hydroxyl-3,4-dimethy-5-penty-12(5H)-furanone) (9),trans-p-hydroxycinnamic acid (10),(+)-syringaresinol (11),β-sitosterol (12),hircinol (13),nudol (14),moscatin (15),batatasin Ⅲ(16),linoleic acid (17),and p-hydroxybenzaldehyde (18).CONCLUSION We obtained structurally unique spiroalkaloid with morphine structure from the genus Liparis.Compounds 2-11 are isolated for the first time from this genus for the first time.
关键词
羊耳蒜/兰科/羊耳蒜属/acortatarin/A/3β-hydroxy-5α,80-Epidioxyergosta-6,22-diene/13-epicupressic/acidKey words
Liparis japonica/Orchidaceae/Liparis/acortatarin A/3β-hydroxy-5α, 8α-epidioxyergosta-6,22-diene/13-epicupressic acid引用本文复制引用
基金项目
上海中医药大学第十批大学生创新活动计划项目资助()
出版年
2018
NETL
NSTL
维普
万方数据