Research Progress of Analysis Methods in vivo for Anti-tumor Drug Liposomes
Anti-tumor drugs have high toxicity and adverse reactions.Liposome formulation can reduce drug toxicity and degrada-tion of drug activity,which is a promising target vector.At present,the pharmacokinetic study of most anti-tumor drug liposomes main-ly takes the total concentration as the index,but the free drugs are the part that really plays the pharmacological effect in vivo.So the separation and determination of the free drugs are very important.Sample pretreatment is a key step in the separation and extraction of free drugs after liposome administration.This article focuses on common detection methods,pretreatment methods and analysis exam-ples,to provide reference for the establishment of analysis methods in vivo for anti-tumor drug liposomes.
anti-tumor drugliposomein vivo analysissample pretreatmentfree concentration
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