药用动物源蛋白质多肽化学组成和生物活性的研究进展
Research Progress in Chemical Compositions and Bioactivities of Medicinal Animal-Derived Proteins Peptides
周凡星 1童明慧 1刘娟 1李蓉 1方爱青 1郭英球 2时贞平 2李娟3
作者信息
- 1. 湖南中医药大学,长沙 410208
- 2. 长沙欧邦生物科技有限公司,长沙 410000
- 3. 湖南中医药大学,长沙 410208;湖南省中药活性物质筛选工程技术研究中心,长沙 410208;湖南省中美老年性退行性疾病治疗药物国际联合研究中心,长沙 410208
- 折叠
摘要
动物药是中药的重要药源之一,近年来,其生物活性物质逐步被发现,尤其是动物药中共有物质——蛋白质和多肽类成分,具有良好的抗菌、抗肿瘤和抗血栓等生物活性.本文选择目前研究较多的蟾蜍科、不同科属的地龙和全蝎等动物来源中药,检索国内外数据库,查阅从1989年至今与动物蛋白质和多肽相关的研究资料,重点综述了这些动物来源蛋白质/多肽的组成、成分分析和生物活性,为动物来源蛋白质和多肽的进一步研究和应用提供参考依据.
Abstract
Animal medicine is one of the important sources of Chinese medicine for disease prevention and treatment.In recent years,its bioactive substances have been gradually discovered,especially the protein and peptide components,which are co-occurring substances in animal medicine,with good biological activities such as antibacterial,anticancer and antithrombotic.In this paper,it was selected animal sources such as toad,different families of earthworms and scorpion,which have been studied more frequently,and searched domestic and international databases to review the research data related to animal proteins and peptides from 1989 to the pres-ent,focusing on reviewing the composition,composition analysis and biological activities of the proteins and peptides of these animal sources,so as to provide a reference basis for further research and application of animal source proteins/peptides.
关键词
动物蛋白质/动物多肽/生物活性/抗菌/纤维蛋白溶解/抗病毒Key words
animal protein/animal peptide/bioactivity/antibacterial/fibrinolysis/antiviral引用本文复制引用
基金项目
国家级大学生创新创业训练计划项目资助(202110541017)
湖南省自然科学基金部门联合基金资助(2023JJ60472)
湖南省卫生健康委科研课题资助(202213055724)
湖南中医药大学中药学一流学科项目资助(校行科字[2018]3号)
出版年
2024
NETL
NSTL
万方数据