Stability and Dissolution Study of Indomethacin Amorphous Solid Dispersion Using Crospovidone as Carrier
OBJECTIVE To prepare the powders and tablets of indomethacin solid dispersion by spray drying method with crospovidone as carrier.METHODS Modulated differential scanning calorimetry,powder X-ray diffraction analysis and Fourier transform infrared were used to investigate the physical state of the drug in carriers and to detect the possible interactions between the drug and carriers in the solid dispersions.RESULTS Indomethacin remained amorphous in the presence of crospovidone when the drug loading was below 20％,and the hydrogen bonds between the drug and carriers were formed in the solid dispersion.Accelerated stability tests demonstrated that the amorphous solid dispersions using crospovidone as carrier were stable when the drug loading was less than 20％.CONCLUSION The solid dispersion tablets prepared with crospovidone exhibited shorter disintegration time and fas-ter dissolution rate compared with the tablets using povidone or copovidone.
NETL
NSTL
万方数据
