摘要
京大戟为传统峻下逐水药,首载于《神农本草经》列入草部毒草类,用于水肿胀满、痰饮积聚、痈肿疔毒等症.京大戟的化学成分含有二萜、三萜、黄酮、香豆素、有机酸及鞣质等.因其毒烈之性,历来强调以炮制品入药,经炮制后,其药性及化学成分发生变化,在加热及酸性条件下,二萜类成分发生氧化、水解和重排等反应使结构发生转化,二萜含量有下降的趋势;而含有苷类化合物发生水解,苷元产物含量有上升的趋势.本研究总结历年文献,系统论述了京大戟炮制历史沿革,以及炮制对化学成分和药理或毒理作用影响的最新研究进展,为毒性饮片的规范化、标准化研究奠定基础.
Abstract
Euphorbia pekinensis is a traditional medicine of draining water,dispersing swelling and dissipating binds,first recorded in Shennong's Herbal Classic of Materia Medica.E.pekinensis is used to treat edama,phlegm-fluid retention,carbuncle swollen and toxic and other disease.The major components of E.pekinensisinclude diterpenoids,triterpenoids,flavonoids,coumarins,organic acids and tannins.E.pekinensis has always emphasized the use of processed products as medicine due to strong toxicity.After process-ing,its drug properties and chemical components are changed,under heating and acidic conditions,diterpenoids undergo oxidation,hydrolysis and rearrangement,which lead to structural transformation and decrease in content,while glycoside-containing compounds undergo hydrolysis,resulting in an increase in the content of aglycones.This paper summarizes the processing history,composition changes,pharmacological effects and toxicity comparison of E.pekinensis by consulting literature over the years,which provides refer-ence for the rational development and utilization of medicinal material resources of E.pekinensis.
基金项目
国家"中医药现代化研究"专项资助(2018YFC1707003)
NETL
NSTL
万方数据