近年来,药物透皮递送因其避免胃肠道反应及疼痛感而逐渐成为最受欢迎的给药方式之一,而皮肤作为富含抗原递呈细胞的器官,其独有的免疫特性为经皮治疗自身免疫性疾病(autoimmune diseases,ADs)提供了优异条件.本文综述由于免疫自我耐受性丧失和自身反应性T细胞异常等多种原因引起的ADs的致病机制,分析透皮药物递送系统(transdermal drug deliv-ery systems,TDDS)对于治疗ADs的优势,总结透皮给药在几种常见ADs中的应用.TDDS将为ADs的治疗与研究提供新思路、新方法.
Research Progress on Transdermal Drug Delivery in Treatment of Autoimmune Diseases
In recent years,transdermal delivery has proven to be one of the most favorable methods among novel drug delivery sys-tems due to avoiding the gastrointestinal tract and reducing systemic side effects.Skin is one of the most immunologically active organs due to the presence of immune cells,such as Langerhans cells(LCs),dermal dendritic cells(dDCs),and T cells.Unique immune properties of the skin offer excellent opportunities for transdermal treatment of autoimmune diseases(ADs).This review highlights the pathogenic mechanism of ADs caused by various reasons such as loss of immune self-tolerance and abnormal autoreactive T cells,and the advantages of transdermal drug delivery for the treatment of ADs,as well as expounds on the application of transdermal drug deliv-ery systems(TDDS)in the treatment of several typical ADs.TDDS will provide new ideas and methods for the treatment and research of autoimmune diseases.
transdermal drug deliveryautoimmune diseaseimmune cellmicroneedle
NETL
NSTL
万方数据
