Rheumatoid arthritis(RA)is a chronic,systemic,and abnormal inflammatory immune response.It is character-ized by the involvement of synovium and multiple organs and the destruction of joints and articular cartilage.In the past 30 years,some promising new compounds and antibodies have been developed to treat RA.The introduction of RA therapeutic drugs and the development of precision medicine have also given rise to several problems related to patients'access to new treatments,choice of the best regimen,cost-effectiveness,prognosis monitoring and efficacy monitoring,especially in terms of low drug response rate,drug resistance and adverse side effects.People attach great importance to the best combination of drugs for the treatment of RA,especially in patients with severe symptoms or early progression.New treatments and mechanisms are needed to solve these problems,and accurate guidelines for drug selection and drug recombination are established.According to the clinical trial database of the National Library of Medicine,this study summarizes the exciting new drugs,and discusses the trends and challenges in the development of RA drugs,which provides a meaningful reference for the accurate treatment and future research direction of RA.
rheumatoid arthritisprecision medicinenew therapydrug development
NETL
NSTL
万方数据
