Development and Application of Cell Membrane Chromatography and Mitochondrial Membrane Chroma-tography Technology
Cell membrane chromatography is a bioaffinity chromatography method which has been developing rapidly in recent years,where the carriers coated with receptor-containing biomembrane are packed to stationary phase and the bioaffinity between com-pound and membrane receptor presents in chromatography process.This method has the advantages of biomimetic,high efficiency and low cost,and has been widely used in drug screening and identifying the affinity between membrane receptor and candidate ligand.Mitochondria,a crucial functional intracellular membrane system,with various drug targets residing in membrane.Recently,signifi-cant research advancements have been made in mitochondrial membrane chromatography technology.In this paper,the recent progres-ses and applications of cell membrane chromatography and mitochondria membrane chromatography are reviewed.
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