OBJECTIVE To synthesize p-toluenesulfonic acid(PTS)and famotidine(FMT)cocrystal in order to improve thesolu-bility of famotidine in water and the permeability.METHODS The cocrystal was prepared by solvent evaporation method combined with ultrasound.The cocrystal was characterized by scanning electron microscopy,differential scanning calorimetry,thermogravimetric analysis,infrared spectroscopy and powder X-ray diffraction.The single crystal structure of FMT-PTS-H2 O(1∶1∶1)was successfully obtained,and the solubility and permeability of the newly synthesized cocrystal were studied.RESULTS After the formation of cocrystal,the water solubility and permeability of FMT increased by 1.54 and 2.29 times,respectively.CONCLUSION Compared with FMT,the solubility and permeability of FMT after the formation of cocrystal were improved.This study provides a method for improving the permeability of biopharmaceutics classification system(BCS)Ⅲ drugs,which will contribute to the development of low permeability drugs.
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