Determination of 32 Elemental Impurities in COVID-19 Vaccine by ICP-OES
OBJECTIVE To establish a method for the determination of 32 elements in COVID-19 vaccine.METHODS The 32 elements were determined by inductively coupled plasma optical emission spectrometer(ICP-OES)through semi-quantitative screen-ing and quantitative detection,and the specificity,linearity,limit of quantification,detection limit and recovery rate of the ICP-OES method were investigated to evaluate the feasibility of the method for the detection of trace elements in vaccines.RESULTS The line-ar relationship of each element was good within the detection mass concentration range,and the recoveries of element added were 94.06％-115.50％.When applied to the detection of the samples at each accelerated placement point,except for the trace contents of B and Si elements,which did not increase significantly after long-term placement,the contents of other elements were far less than the prescribed limits.CONCLUSION The ICP-OES method is established And the method has good specificity,reliable results,simple and rapid,and is suitable for the determination of 32 elements in COVID-19 vaccine.
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