Research Progress of Compounds Inducing Cellular Mitophagy
Autophagy is a kind of programmed cell death that maintains metabolic and energetic homeostasis in organisms,which involves degradation of proteins,organelles,and other components.Mitophagy is a highly selective autophagy,which achieves its own metabolites and energy requirements by degrading excess or damaged mitochondria.Mitophagy plays an important role in the develop-ment of diseases,as one of selective autophagy most studied up to now.Some compounds have been found to induce mitophagy in cells through different mitochondrial signaling pathways,affecting the disease.In the current review,we summarized the mechanism of mito-phagy induction and compounds that induce mitophagy are summarized,with the aim to provide a reference for the research and devel-opment of new drugs targeting mitochondria.
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