Research Progress in Research on Methyltransferase-like Protein Family in Cancer Diseases
Methyltransferase-like proteins(METTL)are a kind of enzyme proteins that exist widely in human body,with a binding domain of nucleic acids,proteins,and other small molecules.METTL catalyzes methylation using S-adenosylmethionine(SAM)as a substrate.Methylation is one of the important modifications of proteins and nucleic acids and is one of the important topics in epigenet-ic.Members of the METTL family are considered to be methyltransferases in the methylation of nucleic acids and proteins,and under-standing the mechanisms by which these potential enzymes act can help understand their functions and substrate specificity.With the development of research,it has been found that METTL family is abnormally expressed in a variety of tumor diseases,and its relation-ship with tumor diseases is clarified.It can be used as a target of molecular therapy and plays an important role in tumor prognosis.In this review,the classification,mechanism of action and relationship between METTL family and tumor were reviewed in order to pro-vide new ideas and new targets for tumor pathogenesis and diagnosis and treatment.