Immune checkpoints(ICs)are the core of immunotherapy.Due to the advantages of strong targeting,long-term efficacy and good patient tolerance,immune checkpoint therapy has become a hot spot for the treatment of some major diseases such as malig-nant tumors.In this paper,the expression and immune mechanism of immunosuppression receptors and immunostimulatory receptors in recent years are summarized,and list the clinical research data of approved drugs targeting immune checkpoint is listed.It provides ref-erence for future research of immune checkpoint and related drugs.
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