OBJECTIVE To analyze the characteristics of methylphenidate(MPH)related treatment emergent adverse events(TEAE)in children,so as to provide recommendations for prevention of MPH safety events.METHODS Case reports of MPH-in-duced TEAE in children were retrieved from CNKI,VIP,Wan Fang,PubMed,Web of Science,EMbase and other databases,and the gender,age,dosage,drug combination,time of adverse reactions and clinical manifestations of the patients were statistically analyzed.RESULTS A total of 39 case reports were collected,involving 50 cases,including 47 cases in the treatment group and 3 cases in the non-treatment group.In the treatment group,the ratio of male to female was 3.7∶1,with 40 cases(80％)in patients aged 6-15 years.Most TEAEs occurred within 1-30 d after drug administration(32 cases,64％),and the TEAEs mainly involved mental sys-tem(12 cases,21.43％)and nervous system(11 cases,19.64％).In the non-treatment group,2 patients were overdosed,and ad-verse reactions occurred within 1 h,mainly involving mental system and nervous system.Among the 50 cases,49 cases were improved after drug withdrawal and/or symptomatic treatment,and 1 case had unknown prognosis.CONCLUSION It is necessary to prevent the possible safety problems in the use of MPH,so as to improve the level of rational drug use.
维普
万方数据