Recent Advances of Nanoparticle-Hydrogel Composite Drug Delivery Systems in Cancer Treatment
Hydrogels and nanoparticles have great application prospects in drug delivery.Hydrogels possess good biocompatibility and physicochemical versatility to enable disease-triggered in situ self-assemble and sustained or stimuli-responsive drug release.The high targeting ability and low toxicity of nanoparticles can significantly improve the delivery efficiency of antitumor drugs.However,hydrogels and nanoparticles still face many challenges in their applications,for example,hydrogels suffer from low mechanical strength and have difficulty in delivering hydrophobic drugs,while nanoparticles have off-target effects and low accumulation and retention in tumors.Therefore,the incorporation of nanoparticles into the hydrogel network can form a novel multifunctional system that enables the hydrogel to serve as a reservoir for the local delivery of nano-drugs into tumors,thereby combining the advantages of two preparations to produce synergistic therapeutic effects.Herein,we review the design of drug release behavior of nanoparticle-hydrogel composite sys-tems,and outline the recent progress of nanoparticle-hydrogel composite systems in the local application of antitumor drugs,including intratumoral and peritumoral injections,subcutaneous or intramuscular injections,transdermal administration and intraluminal adminis-tration,providing insights and references for the rational design of novel anti-tumor dosage forms and preparations.
nanoparticlehydrogelcomposite drug delivery systemtumorlocal treatment
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