水凝粒子激光计数检测器在药物分析中的研究进展
Nano Quantity Analyte Detector and Its Application in Pharmaceutical Analysis
罗英 1洪利娅 1龚青 1刘柱 1石云峰 1陈爽 1朱价1
作者信息
- 1. 浙江省食品药品检验研究院,国家药监局仿制药评价关键技术重点实验室,杭州 310052
- 折叠
摘要
水凝粒子激光计数检测器(nano quantity analyte detector,NQAD)是近年来发展起来的基于气溶胶原理的通用型检测器,其响应值不依赖于待测组分的化学结构而仅与其气溶胶颗粒尺寸和数量有关,同时具有线性范围宽、灵敏度高、受环境影响小、计算方便、操作简单等特点,尤其适用于无紫外吸收、难离子化、没有电化学活性等物质的分析,在一定程度上弥补了其他检测器的不足.笔者简要综述了 NQAD检测器的工作原理、检测特点和优势,及其在药物分析领域中的应用,并对其在药品质量控制中的应用进行展望.
Abstract
Nano quantity analyte detector(NQAD)is a universal detector based on the principle of aerosol developed in recent years.The detector response is not dependent on the chemical structure of the analyte,but only on the size and quantity of aerosol par-ticles.With the characteristic of wide range of linearity,high sensitivity,simplicity of calculation,operation and stable,NQAD is suit-able for those analytes of non-ultraviolet absorption,difficult ionization,non-electrochemical activity,which makes up for the deficien-cies of other detectors.In this paper,the operating principle,characteristics,and advantages of NQAD and its application in pharma-ceutical analysis are reviewed,and the application in drug quality control is prospected.
关键词
水凝粒子激光计数检测器/气溶胶/药物分析/质量控制Key words
nano quantity analyte detector/aerosol/pharmaceutical analysis/quality control引用本文复制引用
出版年
2024
NETL
NSTL
万方数据